Department of Endocrinology, Hebei General Hospital, 348, Heping West Road, Shijiazhuang, 050051, Hebei, China.
Pediatric Orthopaedics, Shijiazhuang the Third Hospital, 15, Sports South Street, Shijiazhuang, 050011, Hebei, China.
BMC Endocr Disord. 2021 Oct 18;21(1):203. doi: 10.1186/s12902-021-00862-y.
The aim of the study was to explore the relationship between vitamin D status and islet function in patients with type 2 diabetes mellitus.
The participants were recruited from Hebei General Hospital. Basic characteristics and blood indicators were collected after fasting overnight. The data were analyzed statistically using SPSS 22.0. Analysis of variance, a nonparametric test, or a trend Chi-square test was used for the comparisons. The association between 25-hydroxy vitamin D and modified homeostasis model assessment-β was assessed using multivariate ordinal logistic regression.
One hundred seventy-four patients aged 26 to 79 years with type 2 diabetes mellitus were included in this study. Patients with vitamin D deficiency had a lower modified homeostasis model assessment-β level compared with those without vitamin D deficiency. There were differences in body mass index, diabetes course, glycosylated hemoglobin, fasting blood glucose, fasting blood C-peptide, triglyceride, and 25-hydroxy vitamin D among different modified homeostasis model assessment-β groups based upon the tertiles. 25-hydroxy vitamin D, as continuous or categorical variables, was positively related to modified homeostasis model assessment-β whether or not cofounding factors were adjusted.
There is an association between increased 25-hydroxy vitamin D levels and improvement in modified homeostasis model assessment-β function in patients with type 2 diabetes mellitus.
Cross-sectional trails ChiCTR2000029391 , Registration Date: 29/01/2020.
本研究旨在探讨 2 型糖尿病患者维生素 D 状态与胰岛功能之间的关系。
研究对象来自河北省人民医院。采集空腹过夜后的基本特征和血液指标。使用 SPSS 22.0 进行统计分析。采用方差分析、非参数检验或趋势卡方检验进行比较。采用多元有序逻辑回归分析 25-羟维生素 D 与改良的稳态模型评估-β之间的关系。
本研究共纳入 174 例年龄 26 至 79 岁的 2 型糖尿病患者。与非维生素 D 缺乏患者相比，维生素 D 缺乏患者的改良稳态模型评估-β水平较低。根据 tertiles，不同改良稳态模型评估-β组的体质指数、糖尿病病程、糖化血红蛋白、空腹血糖、空腹 C 肽、甘油三酯和 25-羟维生素 D 存在差异。无论是否调整混杂因素，25-羟维生素 D 作为连续或分类变量，与改良的稳态模型评估-β呈正相关。
2 型糖尿病患者 25-羟维生素 D 水平升高与改良的稳态模型评估-β功能改善有关。
前瞻性临床试验 ChiCTR2000029391，注册日期：2020 年 1 月 29 日。
