血浆铬对 2 型糖尿病患者血脂谱、糖代谢和心血管风险的影响：病例对照研究。
The effects of plasma chromium on lipid profile, glucose metabolism and cardiovascular risk in type 2 diabetes mellitus. A case - control study.
机构信息
Department of Molecular Medicine, School of Medical Science, Kwame Nkrumah University of Science and Technology (KNUST), Kumasi, Ghana.
Department of Chemical Pathology, University of Cape Coast,- Ghana.
出版信息
PLoS One. 2018 Jul 5;13(7):e0197977. doi: 10.1371/journal.pone.0197977. eCollection 2018.
BACKGROUND
The study was aimed at determining the effect of plasma chromium concentration on the metabolism of glucose, and lipids and their subsequent cardiovascular risk in patients with type 2 diabetes in the Bolgatanga district of Ghana.
MATERIAL AND METHODS
Fasting blood glucose and lipids profile were determined by enzymatic assay using the BT 5000® Random Access Chemistry Analyzer. Fasting serum insulin and High sensitive C-reactive protein were determined by ELISA, a solid phase direct sandwich immunoassay method. HOMA-IR, which is based on fasting blood sample for insulin and glucose concentrations measured in a single blood sample, was used to calculate insulin resistance. Plasma chromium was measured using an atomic Absorption Spectrometer.
RESULTS
Patientswith diabeteshad significantly (p<0.0001) increased LDL, TC, TG, VLDL, insulin, CRP and HOMAIR and a significantly reduced plasma chromium (p<0.0001) (0.53± 0.02μg/l and 0.11±0.01μg/l control and case respectively). Low Cr (p ≤0.001) was associated with high blood pressure, obesity and lipid dysregulation. Plasma Cr significantly correlated negatively with blood pressure and LDL.
CONCLUSION
Lower plasma Cr level was associated with hyperglycaemia, hyperinsulinemia, hypertension, insulin resistance and high inflammation marker HsCRP.
背景
本研究旨在确定加纳博尔加坦加地区 2 型糖尿病患者血浆铬浓度对葡萄糖和脂质代谢及其随后心血管风险的影响。
材料与方法
采用 BT 5000®随机访问化学分析仪，通过酶联免疫吸附试验测定空腹血糖和血脂谱。采用酶联免疫吸附试验测定空腹血清胰岛素和高敏 C 反应蛋白，采用固相直接夹心免疫测定法。基于单一样本中测量的胰岛素和葡萄糖浓度的空腹血样，使用 HOMA-IR 计算胰岛素抵抗。采用原子吸收光谱仪测量血浆铬。
结果
糖尿病患者的 LDL、TC、TG、VLDL、胰岛素、CRP 和 HOMAIR 显著升高（p<0.0001），而血浆铬显著降低（p<0.0001）（对照组和病例组分别为 0.53±0.02μg/l 和 0.11±0.01μg/l）。低 Cr（p≤0.001）与高血压、肥胖和脂质失调有关。血浆 Cr 与血压和 LDL 呈显著负相关。
结论
较低的血浆 Cr 水平与高血糖、高胰岛素血症、高血压、胰岛素抵抗和高炎症标志物 HsCRP 有关。
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