肥胖的营养不良：促进糖尿病发生的微量营养素缺乏
The malnutrition of obesity: micronutrient deficiencies that promote diabetes.
作者信息
Via Michael
机构信息
Division of Endocrinology and Metabolism, Beth Israel Medical Center, Albert Einstein College of Medicine, 55 East 34th St, USA.
出版信息
ISRN Endocrinol. 2012;2012:103472. doi: 10.5402/2012/103472. Epub 2012 Mar 15.
Abstract
Obesity and diabetes are increasing in prevalence worldwide. Despite excessive dietary consumption, obese individuals have high rates of micronutrient deficiencies. Deficiencies of specific vitamins and minerals that play important roles in glucose metabolism and insulin signaling pathways may contribute to the development of diabetes in the obese population. This paper reviews the current evidence supporting this hypothesis.
摘要
肥胖症和糖尿病在全球范围内的患病率正在上升。尽管饮食摄入过多，但肥胖个体的微量营养素缺乏率却很高。在葡萄糖代谢和胰岛素信号通路中起重要作用的特定维生素和矿物质的缺乏，可能会促使肥胖人群患糖尿病。本文综述了支持这一假说的现有证据。
相似文献
1
The malnutrition of obesity: micronutrient deficiencies that promote diabetes.肥胖的营养不良：促进糖尿病发生的微量营养素缺乏
ISRN Endocrinol. 2012;2012:103472. doi: 10.5402/2012/103472. Epub 2012 Mar 15.
2
Micronutrient Deficiency in Children and Adolescents with Obesity-A Narrative Review.肥胖儿童和青少年的微量营养素缺乏——一篇叙述性综述
Children (Basel). 2023 Apr 7;10(4):695. doi: 10.3390/children10040695.
3
Feeding the critically ill obese patient: a systematic review protocol.为危重症肥胖患者提供营养支持：一项系统评价方案
JBI Database System Rev Implement Rep. 2015 Oct;13(10):95-109. doi: 10.11124/jbisrir-2015-2458.
4
Prevalence and determinants of micronutrient deficiencies in malnourished older hospitalized patients.营养不良的老年住院患者的微量营养素缺乏的患病率和决定因素。
J Nutr Health Aging. 2024 Feb;28(2):100039. doi: 10.1016/j.jnha.2024.100039. Epub 2024 Jan 26.
5
Large-scale staple food fortification as a complementary strategy to address vitamin and mineral vulnerabilities in India: A critical review.大规模主食强化作为解决印度维生素和矿物质脆弱性的补充策略：批判性评价。
Indian J Public Health. 2022 Jul-Sep;66(3):313-320. doi: 10.4103/ijph.ijph_708_22.
6
Nutrient deficiencies prior to bariatric surgery.减重手术前的营养缺乏。
Curr Opin Clin Nutr Metab Care. 2017 Mar;20(2):138-144. doi: 10.1097/MCO.0000000000000352.
7
Micronutrient deficiency in obese subjects undergoing low calorie diet.肥胖患者在接受低热量饮食时的微量营养素缺乏。
Nutr J. 2012 Jun 1;11:34. doi: 10.1186/1475-2891-11-34.
8
Fighting Obesity-Related Micronutrient Deficiencies through Biofortification of Agri-Food Crops with Sustainable Fertilization Practices.通过采用可持续施肥措施对农业粮食作物进行生物强化来对抗与肥胖相关的微量营养素缺乏症。
Plants (Basel). 2022 Dec 12;11(24):3477. doi: 10.3390/plants11243477.
9
Micronutrient Status in Sri Lanka: A Review.斯里兰卡微量营养素状况：综述。
Nutrients. 2018 Oct 27;10(11):1583. doi: 10.3390/nu10111583.
10
Impact of micronutrient deficiencies on obesity.微量营养素缺乏对肥胖的影响。
Nutr Rev. 2009 Oct;67(10):559-72. doi: 10.1111/j.1753-4887.2009.00228.x.
引用本文的文献
1
Long-term effects of gastric bypass and sleeve gastrectomy in type 2 diabetes: a matched retrospective cohort study from Sweden.胃旁路手术和袖状胃切除术对2型糖尿病的长期影响：一项来自瑞典的配对回顾性队列研究。
Lancet Reg Health Eur. 2025 Aug 30;58:101430. doi: 10.1016/j.lanepe.2025.101430. eCollection 2025 Nov.
2
Predicting Metabolic and Cardiovascular Healthy from Nutritional Patterns and Psychological State Among Overweight and Obese Young Adults: A Neural Network Approach.通过超重和肥胖青年成人的营养模式和心理状态预测代谢和心血管健康：一种神经网络方法。
Nutrients. 2025 Aug 15;17(16):2651. doi: 10.3390/nu17162651.
3
Burden of micronutrient deficiency among patients with type 2 diabetes: systematic review and meta-analysis.2型糖尿病患者中微量营养素缺乏的负担：系统评价与荟萃分析
BMJ Nutr Prev Health. 2025 Jan 29;8(1):e000950. doi: 10.1136/bmjnph-2024-000950. eCollection 2025.
4
Demographic variation and socioeconomic inequalities in all forms of malnutrition among children aged 6 months to 9 years: findings from the Vietnamese General Nutrition Survey 2020.6个月至9岁儿童各种形式营养不良的人口统计学差异和社会经济不平等：越南2020年综合营养调查结果
BMJ Public Health. 2025 Feb 4;3(1):e001177. doi: 10.1136/bmjph-2024-001177. eCollection 2025.
5
Nutritionally acquired immunodeficiency must be addressed with the same urgency as HIV to end tuberculosis.为终结结核病，必须以与应对艾滋病毒相同的紧迫性来应对营养性获得性免疫缺陷。
BMC Glob Public Health. 2024 Jan 12;2(1):4. doi: 10.1186/s44263-023-00035-0.
6
Does cardiorespiratory fitness moderate the relationship between overweight, cardiovascular risk markers and mental health among forcibly displaced individuals living in a Greek refugee camp?心肺适能是否会缓和居住在希腊难民营中的被迫流离失所者超重、心血管风险标志物与心理健康之间的关系？
Front Sports Act Living. 2024 Oct 21;6:1334230. doi: 10.3389/fspor.2024.1334230. eCollection 2024.
7
The impact of energy releasing B-vitamin intake on indices of obesity and cardiac function: a cross-sectional study.释放能量的B族维生素摄入对肥胖指标和心脏功能的影响：一项横断面研究
F1000Res. 2024 Aug 6;12:1382. doi: 10.12688/f1000research.139672.2. eCollection 2023.
8
Functional roles of pantothenic acid, riboflavin, thiamine, and choline in adipocyte browning in chemically induced human brown adipocytes.泛酸、核黄素、硫胺素和胆碱在化学诱导的人棕色脂肪细胞中脂肪细胞棕色化中的功能作用。
Sci Rep. 2024 Aug 6;14(1):18252. doi: 10.1038/s41598-024-69364-w.
9
Correlation between serum sex hormone-binding globulin levels and nutrition indicators and malnutrition exposure risk in men and postmenopausal women with type 2 diabetes.2型糖尿病男性及绝经后女性血清性激素结合球蛋白水平与营养指标及营养不良暴露风险的相关性
BMC Endocr Disord. 2024 Jul 17;24(1):117. doi: 10.1186/s12902-024-01653-x.
10
Biotin Homeostasis and Human Disorders: Recent Findings and Perspectives.生物素稳态与人类疾病：最新发现与展望。
Int J Mol Sci. 2024 Jun 14;25(12):6578. doi: 10.3390/ijms25126578.
本文引用的文献
1
Vitamin D and diabetes: its importance for beta cell and immune function.维生素 D 与糖尿病：对胰岛β细胞和免疫功能的重要性。
Mol Cell Endocrinol. 2011 Dec 5;347(1-2):106-20. doi: 10.1016/j.mce.2011.08.016. Epub 2011 Aug 26.
2
Obesity epidemic: overview, pathophysiology, and the intensive care unit conundrum.肥胖症流行：概述、病理生理学和重症监护室的难题。
JPEN J Parenter Enteral Nutr. 2011 Sep;35(5 Suppl):4S-13S. doi: 10.1177/0148607111415110.
3
The global obesity pandemic: shaped by global drivers and local environments.全球肥胖症大流行：由全球驱动因素和本地环境共同塑造。
Lancet. 2011 Aug 27;378(9793):804-14. doi: 10.1016/S0140-6736(11)60813-1.
4
Diabetes prevalence is associated with serum 25-hydroxyvitamin D and 1,25-dihydroxyvitamin D in US middle-aged Caucasian men and women: a cross-sectional analysis within the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial.在美国中年白种男性和女性中，糖尿病患病率与血清 25-羟维生素 D 和 1,25-二羟维生素 D 有关：前列腺癌、肺癌、结直肠癌和卵巢癌筛查试验中的一项横断面分析。
Br J Nutr. 2011 Aug;106(3):339-44. doi: 10.1017/S0007114511001590. Epub 2011 May 17.
5
Vitamin D and type 2 diabetes: a systematic review.维生素 D 与 2 型糖尿病：系统综述。
Eur J Clin Nutr. 2011 Sep;65(9):1005-15. doi: 10.1038/ejcn.2011.118. Epub 2011 Jul 6.
6
Effects of vitamin D and calcium supplementation on pancreatic β cell function, insulin sensitivity, and glycemia in adults at high risk of diabetes: the Calcium and Vitamin D for Diabetes Mellitus (CaDDM) randomized controlled trial.维生素 D 和钙补充对糖尿病高危成人的胰岛 β 细胞功能、胰岛素敏感性和血糖的影响：钙和维生素 D 治疗糖尿病（CaDDM）随机对照试验。
Am J Clin Nutr. 2011 Aug;94(2):486-94. doi: 10.3945/ajcn.111.011684. Epub 2011 Jun 29.
7
Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline.维生素 D 缺乏的评估、治疗和预防：内分泌学会临床实践指南。
J Clin Endocrinol Metab. 2011 Jul;96(7):1911-30. doi: 10.1210/jc.2011-0385. Epub 2011 Jun 6.
8
Effects of biotin deficiency on pancreatic islet morphology, insulin sensitivity and glucose homeostasis.生物素缺乏对胰岛形态、胰岛素敏感性和血糖稳态的影响。
J Nutr Biochem. 2012 Apr;23(4):392-9. doi: 10.1016/j.jnutbio.2011.01.003. Epub 2011 May 18.
9
Thiamine deficiency in diabetes mellitus and the impact of thiamine replacement on glucose metabolism and vascular disease.糖尿病中的硫胺素缺乏及硫胺素补充对葡萄糖代谢和血管疾病的影响。
Int J Clin Pract. 2011 Jun;65(6):684-90. doi: 10.1111/j.1742-1241.2011.02680.x.
10
American Association of Clinical Endocrinologists Medical Guidelines for clinical practice for developing a diabetes mellitus comprehensive care plan: executive summary.美国临床内分泌医师协会糖尿病综合护理计划制定临床实践医学指南：执行摘要
Endocr Pract. 2011 Mar-Apr;17(2):287-302. doi: 10.4158/ep.17.2.287.
Zotero 插件