Watanabe N, Kojima S, Ovary Z
J Immunol. 1977 Jan;118(1):251-5.
A/J and DBA/1 mice were infected with 750 third-stage larvae of Nippostrongylus brasiliensis and immunized with 1 mug dinitrophenylated N. brasiliensis extract (DNP-Nb) with 1 mg Al(OH)3 to produce high titers of anti-hapten IgG1 and IgE antibody. Partial tolerance to the production of anti-hapten IgG1 and IgE antibody could be induced by DNP-Ficoll from 5 weeks before to 1 week after the DNP-Nb immunization. The tolerized state persisted through the duration of the experiments. However, no tolerizing effect could be demonstrated on secondary antihapten IgE antibody production induced by DNP-Nb. Moreover, DNP-Ficoll failed to evoke anti-hapten IgG1 or IgE antibody production.
将A/J和DBA/1小鼠感染巴西日圆线虫750条三期幼虫感染小鼠，并用1微克二硝基苯基化巴西日圆线虫提取物（DNP-Nb）与1毫克氢氧化铝免疫，以产生高滴度的抗半抗原IgG1和IgE抗体。在DNP-Nb免疫前5周直至免疫后1周，DNP-菲可诱导对半抗原IgG1和IgE抗体产生部分耐受性。耐受状态在整个实验期间持续存在。然而，对于DNP-Nb诱导的继发性抗半抗原IgE抗体产生，未显示出耐受作用。此外，DNP-菲可未能引发抗半抗原IgG1或IgE抗体产生。
