Klaus G G, Phillips J M, Humphrey J H, Dresser D W, Cross A M
Eur J Immunol. 1976 Jun;6(6):429-33. doi: 10.1002/eji.1830060610.
Dinitrophenylated polysucrose (DNP-Ficoll) elicits T cell-independent IgM anti-DNP antibody formation in mice. This antigen also elicits a heterogeneous IgG1 and IgG2 anti-DNP response, which is operationally as T-independent as the IgM response. However, a concomitant graft-versus-host reaction markedly enhances the IgG response (allogeneic effect). These results confirm those of others, indicating that a certain proportion of the precursors of IgG-producing cells can be triggered by some T-independent antigens. However, our results suggest that even with such antigens optimal triggering of IgG precursors requires T cell help.
二硝基苯基化聚蔗糖（DNP-菲可）能在小鼠体内引发非T细胞依赖性IgM抗DNP抗体的形成。这种抗原还能引发异质性的IgG1和IgG2抗DNP反应，在操作上与IgM反应一样是非T细胞依赖性的。然而，同时发生的移植物抗宿主反应会显著增强IgG反应（同种异体效应）。这些结果证实了其他人的结果，表明产生IgG的细胞的某些前体可以被一些非T细胞依赖性抗原触发。然而，我们的结果表明，即使对于这类抗原，IgG前体的最佳触发也需要T细胞的帮助。
