P.G. Department of Biotechnology, Academy of Management & Information Technology, Khurda, 752057, Odisha, India.
Research Institute of Biotechnology and Medical Converged Science, Dongguk University-Seoul, Gyeonggi-do, 10326, Republic of Korea.
J Food Drug Anal. 2018 Jul;26(3):927-939. doi: 10.1016/j.jfda.2018.01.002. Epub 2018 Feb 2.
Humans are a unique reservoir of heterogeneous and vivacious group of microbes, which together forms the human-microbiome superorganism. Human gut serves as a home to over 100-1000 microbial species, which primarily modulate the host internal environment and thereby, play a major role in host health. This spectacular symbiotic relationship has attracted extensive research in this field. More specifically, these organisms play key roles in defense function, eupepsia along with catabolism and anabolism, and impact brain-gut responses. The emergence of microbiota with resistance and tolerance to existing conventional drugs and antibiotics has decreased the drug efficacies. Furthermore, the modern biotechnology mediated nano-encapsulated multiplex supplements appear to be high cost and inconvenient. Henceforth, a simple, low-cost, receptive and intrinsic approach to achieve health benefits is vital in the present era. Supplementation with probiotics, prebiotics, and synbiotics has shown promising results against various enteric pathogens due to their unique ability to compete with pathogenic microbiota for adhesion sites, to alienate pathogens or to stimulate, modulate and regulate the host's immune response by initiating the activation of specific genes in and outside the host intestinal tract. Probiotics have also been shown to regulate fat storage and stimulate intestinal angiogenesis. Hence, this study aims to underline the possible beneficial impact of probiotics for human health and medical sectors and for better lifestyle.
人类是一个独特的、充满异质性和活力的微生物群体的储存库，这些微生物共同构成了人类微生物超级生物体。人类肠道是超过 100-1000 种微生物的家园，这些微生物主要调节宿主的内部环境，从而在宿主健康中发挥重要作用。这种壮观的共生关系吸引了该领域的广泛研究。更具体地说，这些生物体在防御功能、消化、新陈代谢以及影响大脑-肠道反应方面发挥着关键作用。具有耐药性和耐受性的微生物菌群的出现降低了现有常规药物和抗生素的疗效。此外，现代生物技术介导的纳米封装多联补充剂似乎成本高且不方便。因此，在当今时代，采用简单、低成本、易于接受和内在的方法来实现健康益处至关重要。益生菌、益生元和合生菌的补充已显示出对各种肠道病原体的有希望的结果，因为它们具有独特的能力，可以与致病性微生物群争夺粘附位点，使病原体异化，或通过启动宿主肠道内外特定基因的激活来刺激、调节和调节宿主的免疫反应。益生菌也被证明可以调节脂肪储存并刺激肠道血管生成。因此，本研究旨在强调益生菌对人类健康和医疗领域以及更好的生活方式的可能有益影响。
