Directed migration: Cells navigate by extracellular vesicles.

Directional cell motility toward a chemical gradient, chemotaxis, is critical during inflammation, embryogenesis, and cancer metastasis. In this issue, Kriebel et al. (2018. https://doi.org/10.1083/jcb.201710170) demonstrate that the key cAMP chemoattractant for amoebas is synthesized within and released from extracellular vesicles to promote chemotaxis.