Escuela de Salud Pública, Facultad de Medicina, Universidad de Chile, 8380453 Santiago, Chile.
Facultad de Ciencias de la Salud, Universidad Católica del Maule, 3480112 Talca, Chile.
Int J Environ Res Public Health. 2018 Jul 5;15(7):1418. doi: 10.3390/ijerph15071418.
The association of total arsenic exposure with impaired glucose tolerance and gestational diabetes has been shown; however, evidence regarding urinary inorganic arsenic in pregnant women is still limited. Our aim was to evaluate the association between urinary inorganic arsenic concentration and gestational diabetes among pregnant women living in Arica, Chile. Cross-sectional study of pregnant women receiving care at primary health centers in urban Arica. The exposure was urinary inorganic arsenic concentration, while gestational diabetes was the outcome. The association was evaluated using multiple logistic regression models adjusted by age, education level, ethnicity, and pre-pregnancy body mass index. 244 pregnant women were surveyed. The median urinary inorganic arsenic was 14.95 μg/L, and the prevalence of gestational diabetes was 8.6%. After adjusting, we did not find a significant association between gestational diabetes and inorganic arsenic exposure tertiles (Odds ratio (OR) 2.98, 95% CI = 0.87⁻10.18), (OR 1.07, 95% CI = 0.26⁻4.33). This study did not provide evidence on the relationship between urinary inorganic arsenic concentration and gestational diabetes. Further research is needed to elucidate the factors underlying this association.
总砷暴露与葡萄糖耐量受损和妊娠糖尿病有关；然而，关于孕妇尿液无机砷的证据仍然有限。我们的目的是评估智利阿里卡市孕妇尿液无机砷浓度与妊娠糖尿病之间的关系。 这是一项在阿里卡市城市初级保健中心接受护理的孕妇的横断面研究。暴露是尿液无机砷浓度，而妊娠糖尿病是结局。使用经过年龄、教育程度、种族和孕前体重指数调整的多因素逻辑回归模型评估关联。 调查了 244 名孕妇。尿液无机砷中位数为 14.95µg/L，妊娠糖尿病患病率为 8.6%。调整后，我们没有发现妊娠糖尿病与无机砷暴露三分位（比值比（OR）2.98，95%CI=0.87⁻10.18）之间存在显著关联，（OR 1.07，95%CI=0.26⁻4.33）。 本研究没有提供尿液无机砷浓度与妊娠糖尿病之间关系的证据。需要进一步研究阐明这一关联的基础因素。
