Division of Chest Medicine, Department of Internal Medicine, Changhua Christian Hospital, Changhua 500, Taiwan.
Medical Research Center, Department of Internal Medicine, Changhua Christian Hospital, Changhua 500, Taiwan.
Sci Rep. 2018 Jul 5;8(1):10192. doi: 10.1038/s41598-018-28532-5.
We studied the combined effect of air pollutant concentrations and meteorological factors [e.g., temperature and atmospheric pressure (AP)] on the acute exacerbation of coronary obstructive pulmonary disease (COPD) in 277 older patients with COPD (240 men and 37 women; average age, 75.3 ± 9.3 years). Average air pollutant concentrations, AP, temperature, and relative humidity corresponding to each of the 7 days before the date of hospitalisation were identified as the case and the two other weekly averages, 4 and 8 weeks prior to admission, were considered the controls. During the warming-up season, COPD exacerbation more likely occurred on days of temperature increase or AP decrease than on other days. Increments in CO, NO and O concentrations were significantly associated with 5%, 11% and 4% increases in COPD exacerbation risks, respectively. During the cooling-down season, increments in PM concentrations were significant risk factors; the exacerbation likely occurred on days of temperature decreases than on other days. Air pollution with increased NO, CO, O and PM concentrations and continual temperature changes (colder during cooling-down seasons or hotter during warning-up seasons) were associated with acute exacerbation of COPD in older patients.
我们研究了空气污染物浓度和气象因素（例如温度和大气压力（AP））对 277 名患有 COPD 的老年患者（240 名男性和 37 名女性；平均年龄 75.3±9.3 岁）的急性加重的综合影响。将入院前 7 天内的平均空气污染物浓度、AP、温度和相对湿度确定为病例，入院前 4 周和 8 周的另外两个每周平均值作为对照。在升温季节，COPD 加重在温度升高或 AP 降低的日子比其他日子更有可能发生。CO、NO 和 O 浓度的增加与 COPD 加重风险分别增加 5%、11%和 4%显著相关。在降温季节，PM 浓度的增加是显著的危险因素；在温度下降的日子里，COPD 加重的可能性比其他日子更大。NO、CO、O 和 PM 浓度增加且持续的温度变化（降温季节更冷或升温季节更热）的空气污染与老年患者 COPD 的急性加重有关。
