Respiratory Department, Peking University Third Hospital, Beijing, China.
COPD. 2013 Jun;10(3):307-15. doi: 10.3109/15412555.2012.744962. Epub 2013 Jan 16.
Numerous studies have reported variable associations between ambient particulate matter (PM) and chronic obstructive pulmonary disease (COPD) hospitalizations and mortality.
To conduct a systematic study assessing the associations between hospitalizations and mortality from COPD and ambient PM10 (particulate matter with aerodynamic diameters ≤ 10 μm, PM10).
Systematic searches were conducted in 6 common electronic databases. A meta-analysis was performed to estimate the odds ratio (OR) to evaluate the relationship between PM10 and COPD hospitalizations and mortality. Publication bias and heterogeneity of samples were tested by Begg funnel plot and Egger test, respectively. Study findings were analyzed using random-effect model and fixed-effect model.
The search yielded 31 studies suitable for the meta-analysis during the period from Jan 1, 2000 to Oct 31, 2011. A 10 μg/m(3) increase in PM10 was associated with a 2.7% (95%CI = 1.9%-3.6%) increase in COPD hospitalizations with an OR of 1.027 (95%CI: 1.019-1.036), and a 1.1% (95%CI: 0.8%-1.4%) increase in COPD mortality with an OR of 1.011 (95%CI: 1.008-1.014).
Ambient PM10 is associated with increased COPD hospitalizations and mortality. Further research is needed to elucidate whether this association is causal and to clarify its mechanisms.
许多研究报告称，环境颗粒物（PM）与慢性阻塞性肺疾病（COPD）住院和死亡之间存在多种关联。
进行系统研究，评估 COPD 住院和死亡与环境 PM10（空气动力学直径≤10μm 的颗粒物，PM10）之间的关联。
在 6 个常见电子数据库中进行系统搜索。进行荟萃分析以估计优势比（OR），以评估 PM10 与 COPD 住院和死亡之间的关系。通过贝叶斯漏斗图和 Egger 检验分别测试发表偏倚和样本异质性。使用随机效应模型和固定效应模型分析研究结果。
在 2000 年 1 月 1 日至 2011 年 10 月 31 日期间，搜索结果得到 31 项适合荟萃分析的研究。PM10 每增加 10μg/m3，COPD 住院的风险增加 2.7%（95%CI=1.9%-3.6%），OR 为 1.027（95%CI：1.019-1.036），COPD 死亡率增加 1.1%（95%CI：0.8%-1.4%），OR 为 1.011（95%CI：1.008-1.014）。
环境 PM10 与 COPD 住院和死亡增加有关。需要进一步研究阐明这种关联是否具有因果关系，并阐明其机制。
