替加环素在一名3个月大的多重耐药婴儿中的应用：病例报告
Tigecycline application in a 3-month-old infant with multiple drug resistant : a case report.
作者信息
Peng Cheng, Wang Xiaofeng, Zhang Jiangwei, Jiang Yi, Hou Xinlin
机构信息
Department of Neonatal Ward, Peking University First Hospital, No. 1, Xi Anmen Street, Xicheng District, Beijing, 100034 China.
出版信息
Gut Pathog. 2018 Jun 22;10:25. doi: 10.1186/s13099-018-0253-x. eCollection 2018.
BACKGROUND
Tigecycline is an 'immature' antibiotic for children. We report the youngest surviving patient who received a complete tigecycline treatment, and no significant adverse effects occurred in the patient.
CASE PRESENTATION
The 3-month old infant suffered from a catheter-associated bloodstream infection by multiple drug resistant . Tigecycline was considered as a salvage therapy to control the severe sepsis. The therapy consisted of 3 mg/kg as a loading dose and 1.5 mg/kg Q12 h as a maintenance dose for 26 days.
CONCLUSION
Current researches are limited in clinical trials directly focused on children. This therapeutic schedule might be safe for patients who are above 3 months old.
背景
替加环素是一种用于儿童的“不成熟”抗生素。我们报告了接受完整替加环素治疗且未出现明显不良反应的最年轻存活患者。
病例介绍
一名3个月大的婴儿因多重耐药菌引起导管相关血流感染。替加环素被视为控制严重脓毒症的挽救疗法。治疗方案为负荷剂量3mg/kg，维持剂量1.5mg/kg，每12小时一次，持续26天。
结论
目前直接针对儿童的临床试验研究有限。这种治疗方案对3个月以上的患者可能是安全的。
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