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高价碘（III）介导的叔碳和苄基碳中心的脱羧乙酰氧基化反应。

Hypervalent iodine(III)-mediated decarboxylative acetoxylation at tertiary and benzylic carbon centers.

作者信息

Kiyokawa Kensuke, Okumatsu Daichi, Minakata Satoshi

机构信息

Department of Applied Chemistry, Graduate School of Engineering, Osaka University, 2-1 Yamadaoka, Suita, Osaka 565-0871, Japan.

出版信息

Beilstein J Org Chem. 2018 May 15;14:1046-1050. doi: 10.3762/bjoc.14.92. eCollection 2018.

DOI:10.3762/bjoc.14.92
PMID:29977378
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6009488/
Abstract

The decarboxylative acetoxylation of carboxylic acids using a combination of PhI(OAc) and I in a CHCl/AcOH mixed solvent is reported. The reaction was successfully applied to two types of carboxylic acids containing an α-quaternary and a benzylic carbon center under mild reaction conditions. The resulting acetates were readily converted into the corresponding alcohols by hydrolysis.

摘要

报道了在CHCl₃/AcOH混合溶剂中使用PhI(OAc)₂和I的组合对羧酸进行脱羧乙酰氧基化反应。该反应在温和的反应条件下成功应用于含有α-季碳和苄基碳中心的两类羧酸。所得的乙酸酯通过水解很容易转化为相应的醇。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5e6/6009488/2f57a4bd56b9/Beilstein_J_Org_Chem-14-1046-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5e6/6009488/ded723caa429/Beilstein_J_Org_Chem-14-1046-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5e6/6009488/0facfb0f7f16/Beilstein_J_Org_Chem-14-1046-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5e6/6009488/f11614f30dce/Beilstein_J_Org_Chem-14-1046-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5e6/6009488/6cd8224d330b/Beilstein_J_Org_Chem-14-1046-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5e6/6009488/2f57a4bd56b9/Beilstein_J_Org_Chem-14-1046-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5e6/6009488/ded723caa429/Beilstein_J_Org_Chem-14-1046-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5e6/6009488/0facfb0f7f16/Beilstein_J_Org_Chem-14-1046-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5e6/6009488/f11614f30dce/Beilstein_J_Org_Chem-14-1046-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5e6/6009488/6cd8224d330b/Beilstein_J_Org_Chem-14-1046-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b5e6/6009488/2f57a4bd56b9/Beilstein_J_Org_Chem-14-1046-g006.jpg

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