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草莓和阿司匹林单独及联合使用对N-亚硝基甲基苄胺诱导的大鼠食管肿瘤发生的抑制作用。

Inhibition of the development of N-nitrosomethylbenzylamine-induced esophageal tumors in rats by strawberries and aspirin, alone and in combination.

作者信息

Pan Pan, Peiffer Daniel S, Huang Yi-Wen, Oshima Kiyoko, Stoner Gary D, Wang Li-Shu

机构信息

Department of Medicine, Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI, USA.

Current: Stritch School of Medicine, Loyola University Chicago, Chicago, IL, USA.

出版信息

J Berry Res. 2018;8(2):137-146. doi: 10.3233/JBR-170291. Epub 2018 May 17.

DOI:10.3233/JBR-170291
PMID:29977412
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6029707/
Abstract

BACKGROUND

Esophageal squamous cell carcinoma (ESCC) is one of two subtypes of esophageal cancer, with high incidence and mortality rates in developing countries.

OBJECTIVE

The current study investigated the potential chemoprotective effects of strawberries and aspirin against the development of rat esophageal papillomas, the precursors to ESCC.

METHODS

Using a prevention model, we administered study diets to rats before, during, and after -nitrosomethylbenzylamine (NMBA) treatment. The effects of the four diets were evaluated: the control diet, 5% strawberry powder in the control diet, 0.01% aspirin in the drinking water, and the combination of strawberries and aspirin. At week 25, we euthanized all the rats and collected their esophagi to quantify tumor incidence, multiplicity, and burden, as well as for molecular analysis.

RESULTS

Both strawberries and aspirin significantly decreased esophageal tumor multiplicity, with the combination causing the most robust suppression. Aspirin alone and the combination decreased the total tumor burden in the esophagus. None of the diets had a significant effect on tumor incidence or the expression of COX-1 and COX-2. Strawberries and aspirin, alone and in combination, significantly suppressed squamous epithelial cell proliferation (PCNA).

CONCLUSIONS

Strawberries, aspirin, and their combination exhibit chemoprotective effects against NMBA-induced esophageal tumors in rats.

摘要

背景

食管鳞状细胞癌（ESCC）是食管癌的两种亚型之一，在发展中国家发病率和死亡率都很高。

目的

本研究调查草莓和阿司匹林对大鼠食管乳头状瘤（ESCC的癌前病变）发生的潜在化学保护作用。

方法

采用预防模型，在大鼠接受亚硝基甲基苄胺（NMBA）治疗前、治疗期间和治疗后给予研究饮食。评估了四种饮食的效果：对照饮食、对照饮食中含5%草莓粉、饮用水中含0.01%阿司匹林以及草莓与阿司匹林的组合。在第25周，对所有大鼠实施安乐死并收集其食管，以量化肿瘤发生率、多发性和负担，并进行分子分析。

结果

草莓和阿司匹林均显著降低食管肿瘤的多发性，两者组合的抑制作用最强。单独使用阿司匹林以及两者组合均降低了食管中的总肿瘤负担。所有饮食对肿瘤发生率或COX - 1和COX - 2的表达均无显著影响。草莓和阿司匹林单独或联合使用均显著抑制鳞状上皮细胞增殖（PCNA）。

结论

草莓、阿司匹林及其组合对NMBA诱导的大鼠食管肿瘤具有化学保护作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a780/6029707/967a029cfb8f/nihms-974640-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a780/6029707/2b748d70c908/nihms-974640-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a780/6029707/cc8b9d9964c6/nihms-974640-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a780/6029707/bd322b90d9d7/nihms-974640-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a780/6029707/967a029cfb8f/nihms-974640-f0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a780/6029707/2b748d70c908/nihms-974640-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a780/6029707/cc8b9d9964c6/nihms-974640-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a780/6029707/bd322b90d9d7/nihms-974640-f0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a780/6029707/967a029cfb8f/nihms-974640-f0004.jpg

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