哌醋甲酯治疗淡漠对视觉注意扫描行为的影响：一项初步研究。
Effect of Methylphenidate for Apathy on Visual Attention Scanning Behavior: a Pilot Study.
作者信息
Chau Sarah A, Herrmann Nathan, Chung Jonathan, Eizenman Moshe, Lanctôt Krista L
机构信息
Neuropsychopharmacology Research Group, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, ON, Canada.
Department of Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada.
出版信息
Can Geriatr J. 2018 Jun 30;21(2):139-142. doi: 10.5770/cgj.21.291. eCollection 2018 Jun.
BACKGROUND
The purpose of this pilot study was to explore the potential of eye-tracking technology in monitoring symptoms and predicting outcomes in apathetic Alzheimer's disease (AD) patients treated with methylphenidate (MTP).
METHODS
Neuropsychological tests and eye-tracking measurements were completed at baseline and following at least four weeks of treatment with MTP (5-10 mg BID). Eye-movements were measured while patients viewed novel and social stimuli. Cognition, behavior, and apathy were assessed using the Standardized Mini-Mental State Exam (sMMSE), Neuropsychiatric Inventory, and Apathy Evaluation Scale (AES), respectively.
RESULTS
Nine patients were included in the analysis (age: median=75, interquartile range=8; sMMSE: median=22, interquartile range=14). Spearman correlations showed that improvement on the AES was associated with increased visual attention towards novel stimuli (ρ=-0.809, =.008). Additionally, lower baseline attention towards social images was associated with improvement on the AES (ρ=0.905, =.001).
CONCLUSIONS
Eye-tracking techniques can be developed as an objective and nonverbal method of monitoring symptoms and treatment outcomes in AD patients.
背景
本初步研究的目的是探索眼动追踪技术在监测接受哌醋甲酯（MTP）治疗的淡漠型阿尔茨海默病（AD）患者症状及预测其预后方面的潜力。
方法
在基线时以及接受MTP（5 - 10毫克，每日两次）至少四周治疗后，完成神经心理学测试和眼动追踪测量。在患者观看新异刺激和社交刺激时测量眼动。分别使用标准化简易精神状态检查（sMMSE）、神经精神科问卷和淡漠评定量表（AES）评估认知、行为和淡漠情况。
结果
9名患者纳入分析（年龄：中位数 = 75，四分位间距 = 8；sMMSE：中位数 = 22，四分位间距 = 14）。Spearman相关性分析显示，AES得分的改善与对新异刺激视觉注意力的增加相关（ρ = -0.809，P = 0.008）。此外，对社交图像较低的基线注意力与AES得分的改善相关（ρ = 0.905，P = 0.001）。
结论
眼动追踪技术可发展成为一种客观且非言语的方法，用于监测AD患者的症状及治疗效果。
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