Lewis Ariane, Lin Jessica, James Herbert, Hill Travis C, Sen Rajeev, Pacione Donato
Department of Neurology, NYU Langone Medical Center, New York, NY, USA.
Department of Neurosurgery, NYU Langone Medical Center, New York, NY, USA.
Neurohospitalist. 2018 Jul;8(3):129-134. doi: 10.1177/1941874417748542. Epub 2018 Jan 21.
Numerous medical society guidelines recommend discontinuation of antibiotics at a maximum of 24 hours after noninstrumented spinal surgery, even when a drain is left in place. As a result of these recommendations, our institution's Neurosurgery Quality Improvement Committee decided to stop administering prolonged prophylactic systemic antibiotics (PPSAs) to patients with drains after noninstrumented spinal surgery.
We retrospectively reviewed data for patients who had noninstrumented spinal surgery performed by a neurosurgeon at our institution between December 2012 and July 2014 (PPSA period) and December 2014 and July 2016 (non-PPSA period) and had a drain left in place postoperatively. In the PPSA period, patients received antibiotics until drain removal. In the non-PPSA period, patients received antibiotics for a maximum of 24 hours.
We identified 58 patients in the PPSA period and 55 in the non-PPSA period. Discontinuation of PPSAs resulted in a nonsignificant increase in the frequency of surgical site infections (SSIs; 0% in the PPSA period vs 4% in the non-PPSA period; = .24).
After discontinuing PPSAs for patients with noninstrumented spinal procedures, as is recommended for quality improvement, we saw a nonsignificant increase in our rate of SSIs. Further monitoring of this population is warranted.
众多医学学会指南建议,非器械辅助脊柱手术后,即使留置引流管,抗生素使用时间最长也不应超过24小时。基于这些建议,我们机构的神经外科质量改进委员会决定,对于非器械辅助脊柱手术后留置引流管的患者,停止使用延长预防性全身抗生素(PPSA)。
我们回顾性分析了2012年12月至2014年7月(PPSA期)以及2014年12月至2016年7月(非PPSA期)在我们机构由神经外科医生进行非器械辅助脊柱手术且术后留置引流管的患者数据。在PPSA期,患者在引流管拔除前一直使用抗生素。在非PPSA期,患者使用抗生素的时间最长为24小时。
我们在PPSA期确定了58例患者,在非PPSA期确定了55例患者。停止使用PPSA后,手术部位感染(SSI)的发生率有非显著性增加(PPSA期为0%,非PPSA期为4%;P = 0.24)。
按照质量改进建议,对于非器械辅助脊柱手术患者停止使用PPSA后,我们发现SSI发生率有非显著性增加。有必要对这一人群进行进一步监测。