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Br J Neurosurg. 2018 Apr;32(2):177-181. doi: 10.1080/02688697.2017.1396284. Epub 2017 Nov 2.
2
Burden of Surgical Site Infections Associated with Select Spine Operations and Involvement of Staphylococcus aureus.与特定脊柱手术相关的手术部位感染负担及金黄色葡萄球菌的感染情况
Surg Infect (Larchmt). 2017 May/Jun;18(4):461-473. doi: 10.1089/sur.2016.186. Epub 2016 Nov 30.
3
New WHO recommendations on intraoperative and postoperative measures for surgical site infection prevention: an evidence-based global perspective.世界卫生组织关于手术部位感染预防的术中及术后措施新建议:基于证据的全球视角。
Lancet Infect Dis. 2016 Dec;16(12):e288-e303. doi: 10.1016/S1473-3099(16)30402-9. Epub 2016 Nov 2.
4
Prolonged prophylactic antibiotics with neurosurgical drains and devices: Are we using them? Do we need them?神经外科引流管和器械的长期预防性抗生素使用:我们在使用吗?我们需要使用吗?
Am J Infect Control. 2016 Dec 1;44(12):1757-1758. doi: 10.1016/j.ajic.2016.06.039. Epub 2016 Oct 6.
5
Antibiotic prophylaxis for subdural and subgaleal drains.预防性使用抗生素治疗硬膜下和皮下引流。
J Neurosurg. 2017 Mar;126(3):908-912. doi: 10.3171/2016.4.JNS16275. Epub 2016 Jun 3.
6
Diagnosis and neurologic status as predictors of surgical site infection in primary cervical spinal surgery.诊断和神经状态作为原发性颈椎手术手术部位感染的预测因素
Spine J. 2016 May;16(5):632-42. doi: 10.1016/j.spinee.2016.01.019. Epub 2016 Jan 22.
7
Antibiotic resistance: are we all doomed?抗生素耐药性:我们都注定要失败吗?
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No additional protection against ventriculitis with prolonged systemic antibiotic prophylaxis for patients treated with antibiotic-coated external ventricular drains.对于使用抗生素涂层外置脑室引流管治疗的患者,延长全身性抗生素预防并不能提供额外的脑室炎防护。
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9
The effect of Clostridium difficile infection on cardiac surgery outcomes.艰难梭菌感染对心脏手术结果的影响。
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Prevalence of antimicrobial use in US acute care hospitals, May-September 2011.2011 年 5 月至 9 月美国急症护理医院抗菌药物使用情况。
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非器械辅助脊柱手术后术后预防性抗生素停用:一项质量改进项目的结果

Discontinuation of Postoperative Prophylactic Antibiotics After Noninstrumented Spinal Surgery: Results of a Quality Improvement Project.

作者信息

Lewis Ariane, Lin Jessica, James Herbert, Hill Travis C, Sen Rajeev, Pacione Donato

机构信息

Department of Neurology, NYU Langone Medical Center, New York, NY, USA.

Department of Neurosurgery, NYU Langone Medical Center, New York, NY, USA.

出版信息

Neurohospitalist. 2018 Jul;8(3):129-134. doi: 10.1177/1941874417748542. Epub 2018 Jan 21.

DOI:10.1177/1941874417748542
PMID:29977443
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6022904/
Abstract

BACKGROUND

Numerous medical society guidelines recommend discontinuation of antibiotics at a maximum of 24 hours after noninstrumented spinal surgery, even when a drain is left in place. As a result of these recommendations, our institution's Neurosurgery Quality Improvement Committee decided to stop administering prolonged prophylactic systemic antibiotics (PPSAs) to patients with drains after noninstrumented spinal surgery.

METHODS

We retrospectively reviewed data for patients who had noninstrumented spinal surgery performed by a neurosurgeon at our institution between December 2012 and July 2014 (PPSA period) and December 2014 and July 2016 (non-PPSA period) and had a drain left in place postoperatively. In the PPSA period, patients received antibiotics until drain removal. In the non-PPSA period, patients received antibiotics for a maximum of 24 hours.

RESULTS

We identified 58 patients in the PPSA period and 55 in the non-PPSA period. Discontinuation of PPSAs resulted in a nonsignificant increase in the frequency of surgical site infections (SSIs; 0% in the PPSA period vs 4% in the non-PPSA period; = .24).

CONCLUSION

After discontinuing PPSAs for patients with noninstrumented spinal procedures, as is recommended for quality improvement, we saw a nonsignificant increase in our rate of SSIs. Further monitoring of this population is warranted.

摘要

背景

众多医学学会指南建议,非器械辅助脊柱手术后,即使留置引流管,抗生素使用时间最长也不应超过24小时。基于这些建议,我们机构的神经外科质量改进委员会决定,对于非器械辅助脊柱手术后留置引流管的患者,停止使用延长预防性全身抗生素(PPSA)。

方法

我们回顾性分析了2012年12月至2014年7月(PPSA期)以及2014年12月至2016年7月(非PPSA期)在我们机构由神经外科医生进行非器械辅助脊柱手术且术后留置引流管的患者数据。在PPSA期,患者在引流管拔除前一直使用抗生素。在非PPSA期,患者使用抗生素的时间最长为24小时。

结果

我们在PPSA期确定了58例患者,在非PPSA期确定了55例患者。停止使用PPSA后,手术部位感染(SSI)的发生率有非显著性增加(PPSA期为0%,非PPSA期为4%;P = 0.24)。

结论

按照质量改进建议,对于非器械辅助脊柱手术患者停止使用PPSA后,我们发现SSI发生率有非显著性增加。有必要对这一人群进行进一步监测。