Zhao Jinghua, Zhang Ming, Li Yue, Zhang Zhiheng, Chen Mingzi, Liu Tao, Zhang Jiantao, Shan Anshan
Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Harbin 150030, China.
College of Animal Science and Technology, Northeast Agriculture University, Harbin 150030, China.
J Vet Res. 2017 Dec 27;61(4):527-533. doi: 10.1515/jvetres-2017-0068. eCollection 2017 Dec.
The purpose of this study was to investigate the therapeutic effect of hydrogen on the therapy of onion poisoned dogs.
A total of 16 adult beagle dogs were divided into two groups (control and hydrogen) and all were fed dehydrated onion powder at the dose of 10 g/kg for three days. The dogs of the experimental group were given subcutaneous injection of 0.2 mL/kg of hydrogen for 12 days after making the poisoned model successful. Blood samples were collected before feeding onions, one day before injecting hydrogen, and 2 h after the injection of hydrogen on days 1, 3, 5, 7, 9, and 12. Control dogs were not treated with hydrogen.
The levels of leukocyte production, anaemia, red blood cell degeneration which was reflected by the values of Heinz body count, haemolytic ratio, and oxidative products in hydrogen treated group were lower than in control dogs on some days. The capacity of medullary haematopoiesis that was based on reticulocyte counts, and the antioxidation in hydrogen group were higher compared with control group. However, the differences in renal function were not obvious in both groups.
Accordingly, it was concluded that subcutaneous injection of hydrogen could alleviate the symptoms in onion poisoned dogs.
本研究旨在探讨氢气对洋葱中毒犬的治疗效果。
将16只成年比格犬分为两组（对照组和氢气组），所有犬均以10 g/kg的剂量喂食脱水洋葱粉，持续三天。在中毒模型成功建立后，实验组犬皮下注射0.2 mL/kg氢气，持续12天。在喂食洋葱前、注射氢气前一天以及注射氢气后第1、3、5、7、9和12天的2小时采集血样。对照组犬不进行氢气治疗。
在某些日子里，氢气治疗组中由海因茨小体计数、溶血率和氧化产物值反映的白细胞生成、贫血、红细胞变性水平低于对照组犬。基于网织红细胞计数的骨髓造血能力以及氢气组的抗氧化能力均高于对照组。然而，两组的肾功能差异不明显。
因此，得出皮下注射氢气可缓解洋葱中毒犬症状的结论。
