Kashiwagi Risa, Yamada Yuya, Ito Yoshito, Mitsui Yuto, Sakaue Takaaki, Iwamoto Ryuya, Saisho Kenji, Tamba Sachiko, Yamamoto Koji, Watanabe Takehiko, Fujimoto Takashi, Iwahashi Hiromi, Matsuzawa Yuji
Department of Endocrinology and Metabolism, Sumitomo Hospital, Osaka, Japan.
Physical Check up Center, Sumitomo Hospital, Osaka, Japan.
J Endocr Soc. 2018 Jun 14;2(7):753-764. doi: 10.1210/js.2018-00033. eCollection 2018 Jul 1.
Low serum adiponectin (Ad) level is an important risk factor for the development of type 2 diabetes mellitus (T2DM).
To determine whether the changes in Ad in subjects with low baseline serum Ad levels can reduce the rate of development of T2DM.
DESIGN/SETTING/PARTICIPANTS: We performed a large-scale longitudinal study of 7052 healthy Japanese men who underwent general health checkups more than twice between April 2007 and May 2015 at the Physical Check up Center, Sumitomo Hospital. The participants were divided into quartile groups according to baseline Ad level. Subjects of the lowest baseline Ad group (≤5.2 μg/mL) were subdivided into quartile subgroups according to the percent change in Ad (%Ad) and into two subgroups according to endpoint Ad (>5.2 and ≤5.2 μg/mL).
The cumulative incidence rate of T2DM.
The cumulative incidence rate of T2DM of the lowest baseline Ad group (≤5.2 μg/mL) was significantly higher than the other quartile groups. The cumulative incidence rates of T2DM were significantly lower in the largest (≥21.5%) and the second largest (9.3% to 21.4%) %Ad-increased subgroups compared with the %Ad-decreased subgroup ( < 0.001 and = 0.005, respectively). The cumulative incidence rates of T2DM were significantly lower in the endpoint Ad >5.2 μg/mL subgroup than in the ≤5.2 μg/mL subgroup ( < 0.001).
Increases in serum Ad levels of at least ~10% or >5.2 μg/mL can potentially reduce the risk of development of T2DM in Japanese men with low baseline Ad levels who are at a high risk of developing T2DM.
血清脂联素（Ad）水平低是2型糖尿病（T2DM）发生的重要危险因素。
确定基线血清Ad水平低的受试者中Ad的变化是否能降低T2DM的发生率。
设计/地点/参与者：我们对7052名健康日本男性进行了一项大规模纵向研究，这些男性于2007年4月至2015年5月期间在住友医院体检中心接受了两次以上的常规健康检查。参与者根据基线Ad水平分为四分位数组。基线Ad水平最低组（≤5.2μg/mL）的受试者根据Ad的变化百分比（%Ad）进一步分为四分位数亚组，并根据终点Ad（>5.2和≤5.2μg/mL）分为两个亚组。
T2DM的累积发病率。
基线Ad水平最低组（≤5.2μg/mL）的T2DM累积发病率显著高于其他四分位数组。与%Ad降低亚组相比，%Ad增加最大（≥21.5%）和第二大（9.3%至21.4%）的亚组中T2DM的累积发病率显著更低（分别为<0.001和=0.005）。终点Ad>5.2μg/mL亚组的T2DM累积发病率显著低于≤5.2μg/mL亚组（<0.001）。
血清Ad水平至少增加约10%或>5.2μg/mL可能降低基线Ad水平低且T2DM发病风险高的日本男性发生T2DM的风险。
