Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL.
Division of Gastroenterology and Hepatology, University of Colorado School of Medicine, Aurora, CO.
Transplantation. 2018 Nov;102(11):1824-1836. doi: 10.1097/TP.0000000000002326.
Donor-derived infections are defined as any infection present in the donor that is transmitted to 1 or more recipients. Donor-derived infections can be categorized into 2 groups: "expected" and "unexpected" infections. Expected transmissions occur when the donor is known to have an infection, such as positive serology for cytomegalovirus, Epstein Barr virus, or hepatitis B core antibody, at the time of donation. Unexpected transmissions occur when a donor has no known infection before donation, but 1 or more transplant recipients develop an infection derived from the common donor. Unexpected infections are estimated to occur in far less than 1% of solid organ transplant recipients. We will review the epidemiology, risk factors, and approaches to prevention and management of donor-derived viral infectious disease transmission in liver transplantation.
供体源性感染是指供体中存在的任何感染，传播给 1 个或多个受者。供体源性感染可分为 2 组：“预期”和“意外”感染。当供者在捐献时已知存在感染，如巨细胞病毒、Epstein Barr 病毒或乙型肝炎核心抗体的血清学阳性，预期传播就会发生。当供者在捐献前没有已知的感染，但 1 个或多个移植受者发生源自共同供者的感染时，就会发生意外传播。据估计，意外感染在实体器官移植受者中不到 1%。我们将回顾肝移植中供体源性病毒感染性疾病传播的流行病学、危险因素以及预防和管理方法。
