肝移植中的供体来源病毒感染。
Donor-derived Viral Infections in Liver Transplantation.
机构信息
Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, Chicago, IL.
Division of Gastroenterology and Hepatology, University of Colorado School of Medicine, Aurora, CO.
出版信息
Transplantation. 2018 Nov;102(11):1824-1836. doi: 10.1097/TP.0000000000002326.
Abstract
Donor-derived infections are defined as any infection present in the donor that is transmitted to 1 or more recipients. Donor-derived infections can be categorized into 2 groups: "expected" and "unexpected" infections. Expected transmissions occur when the donor is known to have an infection, such as positive serology for cytomegalovirus, Epstein Barr virus, or hepatitis B core antibody, at the time of donation. Unexpected transmissions occur when a donor has no known infection before donation, but 1 or more transplant recipients develop an infection derived from the common donor. Unexpected infections are estimated to occur in far less than 1% of solid organ transplant recipients. We will review the epidemiology, risk factors, and approaches to prevention and management of donor-derived viral infectious disease transmission in liver transplantation.
摘要
供体源性感染是指供体中存在的任何感染，传播给 1 个或多个受者。供体源性感染可分为 2 组：“预期”和“意外”感染。当供者在捐献时已知存在感染，如巨细胞病毒、Epstein Barr 病毒或乙型肝炎核心抗体的血清学阳性，预期传播就会发生。当供者在捐献前没有已知的感染，但 1 个或多个移植受者发生源自共同供者的感染时，就会发生意外传播。据估计，意外感染在实体器官移植受者中不到 1%。我们将回顾肝移植中供体源性病毒感染性疾病传播的流行病学、危险因素以及预防和管理方法。
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