通过临床宏基因组测序诊断的肺移植受者中的戊型肝炎病毒相关性脑膜脑炎
Hepatitis E Virus-Associated Meningoencephalitis in a Lung Transplant Recipient Diagnosed by Clinical Metagenomic Sequencing.
作者信息
Murkey Jamie A, Chew Kara W, Carlson Margrit, Shannon Chelsea L, Sirohi Deepika, Sample Hannah A, Wilson Michael R, Vespa Paul, Humphries Romney M, Miller Steve, Klausner Jeffrey D, Chiu Charles Y
机构信息
Department of Medicine.
Department of Laboratory Medicine.
出版信息
Open Forum Infect Dis. 2017 Jun 13;4(3):ofx121. doi: 10.1093/ofid/ofx121. eCollection 2017 Summer.
Abstract
Hepatitis E virus (HEV) infection uncommonly causes chronic hepatitis and neurologic disease. We describe a case of genotype 3a HEV meningoencephalitis diagnosed by metagenomic next-generation sequencing, illustrating the power of an unbiased molecular approach to microbial testing and the first reported case of HEV infection presumably acquired through lung transplantation.
摘要
戊型肝炎病毒（HEV）感染很少引起慢性肝炎和神经疾病。我们描述了一例通过宏基因组下一代测序诊断出的3a型HEV脑膜脑炎病例，展示了一种无偏倚的微生物检测分子方法的作用，以及首例据推测通过肺移植获得的HEV感染病例。
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