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患有阿谢曼综合征的不孕女性的月经周期模式、宫腔镜检查分期与子宫内膜厚度之间的关联。

The association between menstrual cycle pattern and hysteroscopic march classification with endometrial thickness among infertile women with Asherman syndrome.

作者信息

Baradwan Saeed, Baradwan Afnan, Al-Jaroudi Dania

机构信息

Department of Obstetrics and Gynecology, Women's Specialized Hospital, King Fahad Medical City, Riyadh Department of Obstetrics and Gynecology, King Abdulaziz University, Jeddah, Saudi Arabia.

出版信息

Medicine (Baltimore). 2018 Jul;97(27):e11314. doi: 10.1097/MD.0000000000011314.

Abstract

Women with Asherman syndrome (AS) have intrauterine adhesions obliterating the uterine cavity. Hysteroscopic March classification describes the adhesions which graded in terms of severity. This study has been designed to assess the prevalence and association between of clinical presentations, potential causes, and hysteroscopic March classification of AS among infertile women with endometrial thickness.A retrospective descriptive study was carried out that included 41 women diagnosed with AS. All of the patients underwent evaluation and detailed history. All cases classified according to March classification of AS were recorded. Patients were divided into 2 groups based on measurement of endometrial thickness. Group A consisted of 26 patients with endometrial thickness ≤5 mm, and group B included 15 patients with endometrial thickness >5 mm.The prevalence of AS was 4.6%. Hypomenorrhea was identified in about 46.3%, and secondary infertility 70.7%. History of induced abortion, curettage, and postpartum hemorrhage were reported among 56.1%, 51.2%, and 31.7%, respectively. AS cases were classified as minimal in 34.1%, moderate 41.5%, and severe among 24.4% as per March classification. Amenorrhea was reported by 23.1% of women in group A, compared to 0% in group B (P = .002). Ten of 26 patients (38.5%) from group A had a severe form of March classification, compared with 0 of 15 patients (0%) in group B. This was statistically significant (P < .001).The thin endometrium associated with amenorrhea and severe form of March classification among patients with AS.

摘要

患有阿谢曼综合征(AS)的女性存在宫腔粘连,使子宫腔闭塞。宫腔镜下March分类描述了粘连情况,并根据严重程度进行分级。本研究旨在评估子宫内膜厚度不同的不孕女性中AS的患病率、临床表现、潜在病因与宫腔镜下March分类之间的关联。开展了一项回顾性描述性研究,纳入41例诊断为AS的女性。所有患者均接受了评估和详细病史询问。记录所有根据AS的March分类进行的病例。根据子宫内膜厚度测量将患者分为两组。A组由26例子宫内膜厚度≤5mm的患者组成,B组包括15例子宫内膜厚度>5mm的患者。AS的患病率为4.6%。约46.3%的患者出现月经过少,70.7%的患者出现继发性不孕。分别有56.1%、51.2%和31.7%的患者报告有人工流产、刮宫和产后出血史。根据March分类,34.1%的AS病例为轻度,41.5%为中度,24.4%为重度。A组23.1%的女性报告有闭经,而B组为0%(P = 0.002)。A组26例患者中有10例(38.5%)为March分类的重度,而B组15例患者中为0例(0%)。这具有统计学意义(P < 0.001)。AS患者中,薄型子宫内膜与闭经及March分类的重度形式相关。

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