[急性白血病患者外周血中性粒细胞体外抗体依赖性细胞介导的细胞毒性作用]
[Antibody-dependent cell-mediated cytotoxicity of peripheral blood neutrophils in vitro in acute leukemia].
作者信息
Guseva S A
出版信息
Tsitologiia. 1985 Sep;27(9):1067-70.
A study was made of in vitro antibody-dependent cellular cytotoxicity of neutrophils of peripheral blood in 14 cases of acute myeloblastic leukemia and in 20 healthy patients (control group). A decrease in the number of neutrophils, carrying receptors to Fc-IgG and to C3b-component of complement was registered compared to the results obtained for healthy people. Besides, the number of cells restoring Nitro-blue tetrazolium and myeloperoxidase activity decreased. The decrease in antibody-dependent cellular cytotoxicity of neutrophils in the cases of acute myeloblastic leukaemia is explained by the deficiency of the cell receptor apparatus and by the decrease in the intracellular metabolism in them.
对14例急性髓细胞白血病患者及20名健康对照者（对照组）外周血中性粒细胞的体外抗体依赖性细胞毒性进行了研究。与健康人相比，携带Fc-IgG受体和补体C3b成分受体的中性粒细胞数量减少。此外，使硝基蓝四氮唑还原及髓过氧化物酶活性恢复的细胞数量也减少。急性髓细胞白血病患者中性粒细胞的抗体依赖性细胞毒性降低是由于细胞受体装置缺陷及细胞内代谢减少所致。
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