Sozańska B
1st Department of Pediatrics, Allergology and Cardiology, Wroclaw Medical University, Wroclaw, Poland.
Allergol Immunopathol (Madr). 2019 Jan-Feb;47(1):79-84. doi: 10.1016/j.aller.2018.03.005. Epub 2018 Jul 3.
Tremendous progress in the ability to identify and test the function of microorganisms in recent years has led to a much better understanding of the role of environmental and host microbiome in the development of immune function, allergic sensitization and asthma. In this review, the most recent findings on the relationships between environmental microbiota, respiratory, intestinal microbiome, the consequences of early-life microbial exposure type and gut-lung microbial axis and the development of asthma and atopy are summarized. The current perspective on gut and airway microbiome manipulation for the primary prevention of allergic diseases and asthma is also discussed.
近年来，在识别和测试微生物功能方面取得了巨大进展，这使人们对环境微生物群和宿主微生物群在免疫功能、过敏致敏和哮喘发展中的作用有了更好的理解。在这篇综述中，总结了关于环境微生物群、呼吸道、肠道微生物群之间的关系、早期微生物暴露类型的后果以及肠-肺微生物轴与哮喘和特应性疾病发展的最新研究结果。还讨论了目前对通过操纵肠道和气道微生物群来一级预防过敏性疾病和哮喘的观点。
