State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, 200237, People's Republic of China.
J Antibiot (Tokyo). 2018 Oct;71(10):838-845. doi: 10.1038/s41429-018-0071-x. Epub 2018 Jul 6.
Two novel cyclopeptides with special skeleton, namely, dolyemycins A (1) and B (2) were isolated from Streptomyces griseus subsp. griseus HYS31 by bio-guided isolation. Their structures were elucidated by detailed analysis of spectroscopic data. These two compounds were cyclopeptides containing eleven amino acids including five unusual amino acids (hydroxyglycine, 3-hydroxyleucine, 3-phenylserine, β-hydroxy-O-methyltyrosine, 2,3-diaminobutyric acid) in both of them and an extra nonprotein amino acids (3-methylaspartic acid) in Dolyemycin B only. Dolyemycins A and B performed antiproliferative activity against human lung cancer A549 cells with IC values of 1.0 and 1.2 µM, respectively.
从灰色链霉菌亚种灰色 HYS31 中通过生物导向分离，分离出两种具有特殊骨架的新型环肽，即多霉素 A（1）和 B（2）。通过详细分析光谱数据阐明了它们的结构。这两种化合物是含有 11 个氨基酸的环肽，其中包括五个不常见的氨基酸（羟甘氨酸、3-羟基亮氨酸、3-苯丙氨酸、β-羟基-O-甲基酪氨酸、2,3-二氨基丁酸），而多霉素 B 中仅含有一个额外的非蛋白质氨基酸（3-甲基天冬氨酸）。多霉素 A 和 B 对人肺癌 A549 细胞表现出抗增殖活性，IC 值分别为 1.0 和 1.2μM。
