Rheumatology and Rehabilitation, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Clinical pathology, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
Clin Rheumatol. 2018 Oct;37(10):2811-2817. doi: 10.1007/s10067-018-4194-z. Epub 2018 Jul 7.
Behçet's disease (BD) is an uncommon autoimmune/autoinflammatory disease. Neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) were investigated in many diseases as a marker of inflammation. In this study, we investigated NLR and PLR in patients with BD as a marker of disease activity and its association with different clinical manifestations. The study included 23 BD patients; their mean age was (32.5 ± 6.76) and M:F ratio was 16:7. Complete blood picture was done for all patients. NLR and PLR were compared in both active and inactive BD patients and its relation with different clinical manifestations was assessed. NLR was higher in active BD patients than in inactive BD patients (P < 0.01). Although both NLR and PLR were correlated with Behçet's Disease Current Activity Form (BDCAF), the correlation of NLR with BDCAF was much stronger than that of PLR. NLR was associated with some mucocutaneous lesions. Both NLR and PLR were associated with articular and GIT manifestations, but also NLR showed more significant results. In our studied patients, both NLR and PLR were not informative about any ongoing ocular activity (P > 0.05). Both ratios were not affected by the presence of neurologic deficits nor previous vascular events (P > 0.05). NLR was superior to PLR as an indicator of disease activity. NLR was closely related to skin manifestations while PLR was not. In our study, both were not considered reliable in representing ocular activity.
白塞病（BD）是一种罕见的自身免疫性/炎症性疾病。中性粒细胞与淋巴细胞比值（NLR）和血小板与淋巴细胞比值（PLR）已在许多疾病中作为炎症标志物进行了研究。在本研究中，我们作为疾病活动的标志物研究了 BD 患者中的 NLR 和 PLR，及其与不同临床表现的关系。该研究纳入了 23 例 BD 患者；他们的平均年龄为（32.5±6.76），男女比例为 16:7。对所有患者进行了全血细胞计数。比较了活动期和非活动期 BD 患者的 NLR 和 PLR，并评估了其与不同临床表现的关系。活动期 BD 患者的 NLR 高于非活动期 BD 患者（P<0.01）。尽管 NLR 和 PLR 均与白塞病活动评分（BDCAF）相关，但 NLR 与 BDCAF 的相关性强于 PLR。NLR 与某些黏膜皮肤病变有关。NLR 和 PLR 均与关节和胃肠道表现相关，但 NLR 显示出更显著的结果。在我们研究的患者中，NLR 和 PLR 均不能提示任何正在进行的眼部活动（P>0.05）。这两个比值均不受神经系统缺陷或先前血管事件的影响（P>0.05）。NLR 优于 PLR，是疾病活动的指标。NLR 与皮肤表现密切相关，而 PLR 则不然。在我们的研究中，两者均不能可靠地代表眼部活动。
