Department of Family Medicine, Faculty of Medicine, Karabuk University, Karabuk, Turkey.
Department of İnternal Medicine and Medical Oncology, Faculty of Medicine, Karabuk University, Karabuk, Turkey.
Med Gas Res. 2023 Apr-Jun;13(2):53-58. doi: 10.4103/2045-9912.344981.
This retrospective self-controlled randomized study was carried out with the participation of 53 patients diagnosed with ankylosing spondylitis according to the modified New York criteria. The patients who did not receive medical treatment or did not change their medical treatment within the last 6 months were included in the study. There was a statistically significant decrease in the patients' neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, monocyte/lymphocyte ratio, C-reactive protein, Visual Analog Scale, Bath Ankylosing Spondylitis Functional Index, and Bath Ankylosing Spondylitis Disease Activity Index scores measured after ozone therapy. There was a positive correlation between neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, mean platelet volume/lymphocyte ratio, monocyte/lymphocyte ratio and C-reactive protein, Visual Analog Scale, Bath Ankylosing Spondylitis Functional Index, Bath Ankylosing Spondylitis Disease Activity Index before and after ozone therapy. Our study revealed that the changes in the decreasing tendency of the markers measured in complete blood count after ozone therapy were correlated with the disease activity, which can contribute to understand the effect of ozone therapy on biomarkers.
本回顾性自身对照随机研究共纳入 53 例符合改良纽约标准的强直性脊柱炎患者，这些患者在过去 6 个月内未接受治疗或未改变治疗方案。臭氧治疗后，患者的中性粒细胞/淋巴细胞比值、血小板/淋巴细胞比值、单核细胞/淋巴细胞比值、C 反应蛋白、视觉模拟评分、巴斯强直性脊柱炎功能指数和巴斯强直性脊柱炎疾病活动指数评分均有统计学意义下降。臭氧治疗前后的中性粒细胞/淋巴细胞比值、血小板/淋巴细胞比值、平均血小板体积/淋巴细胞比值、单核细胞/淋巴细胞比值与 C 反应蛋白、视觉模拟评分、巴斯强直性脊柱炎功能指数、巴斯强直性脊柱炎疾病活动指数呈正相关。我们的研究表明，臭氧治疗后全血细胞计数中标志物下降趋势的变化与疾病活动度相关，这有助于了解臭氧治疗对生物标志物的影响。
