Department of Cardiology, Gulhane Medical Academy, Ankara, Turkey.
Department of Cardiology, Eskişehir Military Hospital, Eskişehir, Turkey
Angiology. 2015 Mar;66(3):291-6. doi: 10.1177/0003319714527638. Epub 2014 Mar 25.
Behçet disease (BD) is associated with endothelial dysfunction and chronic inflammation. The neutrophil-lymphocyte (N/L) ratio and carotid intima-media thickness (cIMT) are markers of inflammation and vascular risk, respectively. We assessed the relationship between cIMT values and N/L ratio in BD (65 patients and 62 control participants). There were statistically significant differences in N/L ratios and cIMT values between the patients with BD and control group (P < .001). There were moderate positive correlations between cIMT value, C-reactive protein, and N/L ratio in patients with BD. Receiver-operating characteristic curve analysis suggested that the optimum N/L ratio cutoff point for patients with BD was 1.29, with a sensitivity, specificity, negative predictive value, and positive predictive value of 97, 77, 96, and 75%, respectively (area under curve: 0.691, 95% confidence interval = 0.600-0.782, P < .001). The N/L ratio may be a useful index of BD activity.
贝赫切特病（BD）与血管内皮功能障碍和慢性炎症有关。中性粒细胞与淋巴细胞比值（N/L）和颈动脉内膜中层厚度（cIMT）分别是炎症和血管风险的标志物。我们评估了 cIMT 值与 BD 患者（65 例患者和 62 名对照组参与者）中 N/L 比值之间的关系。BD 患者的 N/L 比值和 cIMT 值与对照组之间存在统计学显著差异（P <.001）。BD 患者的 cIMT 值、C 反应蛋白与 N/L 比值之间存在中度正相关。受试者工作特征曲线分析表明，BD 患者的最佳 N/L 比值临界值为 1.29，其敏感性、特异性、阴性预测值和阳性预测值分别为 97%、77%、96%和 75%（曲线下面积：0.691，95%置信区间=0.600-0.782，P <.001）。N/L 比值可能是 BD 活动的一个有用指标。
