质子束治疗后正常肝组织的变化。

Normal liver tissue change after proton beam therapy.

作者信息

Fukumitsu Nobuyoshi, Takahashi Shinsei, Okumura Toshiyuki, Ishida Toshiki, Murofushi Keiko Nemoto, Ohnishi Kayoko, Aihara Teruhito, Ishikawa Hitoshi, Tsuboi Koji, Sakurai Hideyuki

机构信息

Proton Medical Research Center, University of Tsukuba, 1-1-1 Tennoudai, Tsukuba, 305-8575, Japan.

出版信息

Jpn J Radiol. 2018 Sep;36(9):559-565. doi: 10.1007/s11604-018-0757-9. Epub 2018 Jul 6.

DOI:10.1007/s11604-018-0757-9

PMID:29980916

Abstract

PURPOSE

Normal liver tissue changes after proton beam therapy (PBT) were investigated in patients at 1 and 2 years after the therapy.

MATERIALS AND METHODS

Changes in normal liver tissue volume were examined. The dose distribution of the normal liver tissue was also simulated on the follow-up CTs.

RESULTS

The normal liver tissue volume was 1149 ± 215 cm before treatment, 1089 ± 188 cm at 1 year, and 1080 ± 236 cm at 2 years after treatment. The normal liver tissue volume was increased in 10 and decreased in 20 patients at 2 years and was smaller than that before the treatment in total (P = 0.03). The simulated volume that received more than 30 Gray equivalent [V30 (cm)] at 1 year was 258 ± 187 cm and that at 2 years (244 ± 171 cm) was smaller than that before treatment (297 ± 140 cm) (P = 0.03).

CONCLUSIONS

The changes in the shape and volume of normal liver tissue are not constant, which cause a large dose distribution discrepancy in the normal liver for 2 years. Therefore, careful consideration of the dose distribution of normal liver tissue is required when planning re-irradiation.

摘要

目的

研究质子束治疗（PBT）后1年和2年患者正常肝组织的变化。

材料与方法

检查正常肝组织体积的变化。还在随访CT上模拟正常肝组织的剂量分布。

结果

治疗前正常肝组织体积为1149±215cm³，治疗后1年为1089±188cm³，治疗后2年为1080±236cm³。2年时，10例患者正常肝组织体积增加，20例患者正常肝组织体积减小，总体上小于治疗前（P = 0.03）。1年时接受超过30格雷当量[V30（cm³）]的模拟体积为258±187cm³，2年时（244±171cm³）小于治疗前（297±140cm³）（P = 0.03）。