Clinica Medica, Department of Medicine and Surgery, University Milano-Bicocca, Via Pergolesi 33, 20052, Monza, Milano, Italy.
IRCCS Multimedica, Sesto San Giovanni, Milan, Italy.
Curr Hypertens Rep. 2018 Jul 6;20(9):74. doi: 10.1007/s11906-018-0874-y.
To evaluate the relation between sleep alterations, with or without breathing disorders, and incidence of hypertension and other cardiovascular diseases RECENT FINDINGS: Several studies have clearly shown the mechanisms linking sleep disorders and cardiovascular diseases. The sympathetic hyperactivity seems to play a fundamental role in favoring and sustaining the increase in blood pressure values. Several other mechanisms also contribute to this effect and to the increase cardiovascular risk. The mechanisms responsible for the increase in blood pressure values in subjects with alteration in sleep quantity and quality, with or without breathing disorders, have been clearly established. The recent findings refer to the result of meta-analysis of cross-sectional studies or longitudinal studies showing a significant association between short sleep duration and hypertension. It has also been shown that sleep fragmentation could be considered the main determinant of the sympathetic activation independently of the frequency and severity of oxygen desaturation.
评估伴有或不伴有呼吸障碍的睡眠改变与高血压和其他心血管疾病发生率之间的关系。
几项研究清楚地阐明了睡眠障碍与心血管疾病之间的关联机制。交感神经活性似乎在促进和维持血压值升高方面起着重要作用。其他一些机制也促成了这种效应和增加心血管风险。在伴有或不伴有呼吸障碍的睡眠数量和质量改变的患者中，导致血压值升高的机制已被明确建立。最近的研究结果涉及横断面研究或纵向研究的荟萃分析结果，这些研究表明睡眠时间短与高血压之间存在显著关联。还表明，睡眠片段化可被视为交感神经激活的主要决定因素，而与氧饱和度下降的频率和严重程度无关。
