ICU Center, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.
J Cell Mol Med. 2018 Sep;22(9):4283-4291. doi: 10.1111/jcmm.13711. Epub 2018 Jul 7.
We carried out this meta-analysis to explore the influence of paraoxonase 1 activity on the susceptibility of diabetes mellitus (DM), diabetic macroangiopathy and diabetic microangiopathy. Relevant studies were identified from PubMed, Web of Science and CNKI without language limitation, following the inclusion and exclusion criteria. Statistical analyses were implemented with the STATA 12.0 statistical software. Thirty-six case-control studies were included in the meta-analyses, in which 35 for the association between paraoxonase 1 activity and DM risk, 8 for diabetic macroangiopathy and 7 for diabetic microangiopathy. Paraoxonase 1 activity was significantly associated with the susceptibility of DM in pooled population (SMD = -1.37, 95% CI = -1.79 ∼ -0.96, P = .000), and Asians (SMD = -2.00, 95% CI = -2.56 ∼ -1.44, P = .000), but not in non-Asians (SMD = -0.44, 95% CI = -0.91 ∼ 0.03, P = .069). However, marked heterogeneity was existed (I = 98.10%, P = .000) and subgroup analyses failed to investigate the sources of heterogeneity. Then, meta-regression was performed and found that ethnicity could explain the observed between-study heterogeneity (P = .002). Meanwhile, significant associations were found between paraoxonase 1 activity and diabetic macroangiopathy (SMD = -1.06, 95% CI = -1.63 ∼ -0.48, P = .000) and diabetic microangiopathy (SMD = -0.72, 95% CI = -1.32 ∼ -0.13, P = .018). In conclusion, paraoxonase 1 activity plays important roles in the risk of DM, diabetic macroangiopathy and microangiopathy with ethnicity differences. Further studies with large sample and well design are needed to confirm these results.
我们进行了这项荟萃分析，以探讨对氧磷酶 1 活性对糖尿病（DM）易感性、糖尿病大血管病变和糖尿病微血管病变的影响。无语言限制地从 PubMed、Web of Science 和中国知网中确定了相关研究，符合纳入和排除标准。使用 STATA 12.0 统计软件进行统计分析。共有 36 项病例对照研究纳入荟萃分析，其中 35 项研究探讨了对氧磷酶 1 活性与 DM 风险的关系，8 项研究探讨了糖尿病大血管病变，7 项研究探讨了糖尿病微血管病变。荟萃分析结果显示，对氧磷酶 1 活性与 DM 易感性显著相关（SMD=-1.37，95%CI=-1.79～-0.96，P=0.000），且在亚洲人群（SMD=-2.00，95%CI=-2.56～-1.44，P=0.000）中存在显著相关性，但在非亚洲人群（SMD=-0.44，95%CI=-0.91～0.03，P=0.069）中不存在显著相关性。然而，存在明显的异质性（I²=98.10%，P=0.000），且亚组分析未能发现异质性的来源。随后进行了元回归分析，发现种族可以解释观察到的研究间异质性（P=0.002）。同时，对氧磷酶 1 活性与糖尿病大血管病变（SMD=-1.06，95%CI=-1.63～-0.48，P=0.000）和糖尿病微血管病变（SMD=-0.72，95%CI=-1.32～-0.13，P=0.018）显著相关。总之，对氧磷酶 1 活性在 DM、糖尿病大血管病变和微血管病变的发生风险中具有重要作用，且具有种族差异。需要进一步开展大样本、设计良好的研究来证实这些结果。
