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An integrated model of alopecia areata biomarkers highlights both T1 and T2 upregulation.

作者信息

Song Teresa, Pavel Ana B, Wen Huei-Chi, Malik Kunal, Estrada Yeriel, Gonzalez Juana, Hashim Peter W, Nia John K, Baum Danielle, Kimmel Grace, Singer Giselle K, Krueger James G, Guttman-Yassky Emma

机构信息

Department of Dermatology, Laboratory of Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, NY; College of Medicine, SUNY Downstate, New York, NY.

Department of Dermatology, Laboratory of Inflammatory Skin Diseases, Icahn School of Medicine at Mount Sinai, New York, NY.

出版信息

J Allergy Clin Immunol. 2018 Nov;142(5):1631-1634.e13. doi: 10.1016/j.jaci.2018.06.029. Epub 2018 Jul 5.

DOI:10.1016/j.jaci.2018.06.029
PMID:29981808
Abstract
摘要

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An integrated model of alopecia areata biomarkers highlights both T1 and T2 upregulation.斑秃生物标志物的综合模型突出了T1和T2的上调。
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Alopecia areata profiling shows TH1, TH2, and IL-23 cytokine activation without parallel TH17/TH22 skewing.斑秃特征分析显示 TH1、TH2 和 IL-23 细胞因子激活，而无平行的 TH17/TH22 偏倚。
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Serum T helper 1 cytokine levels are greater in patients with alopecia areata regardless of severity or atopy.斑秃患者的血清辅助性 T 细胞 1 细胞因子水平无论严重程度或特应性如何均较高。
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Biomarkers of alopecia areata disease activity and response to corticosteroid treatment.斑秃疾病活动度及对皮质类固醇治疗反应的生物标志物。
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Front Immunol. 2025 Aug 7;16:1643709. doi: 10.3389/fimmu.2025.1643709. eCollection 2025.
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Multiomics Analysis of the Response to Ritlecitinib in Alopecia Areata Subtypes and Correlation With Efficacy.斑秃亚型对利特昔替尼反应的多组学分析及其与疗效的相关性
Allergy. 2025 Aug;80(8):2348-2360. doi: 10.1111/all.16659. Epub 2025 Jul 14.
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Alopecia Areata: Pathogenesis, Diagnosis, and Therapies.
斑秃：发病机制、诊断与治疗
MedComm (2020). 2025 Apr 21;6(5):e70182. doi: 10.1002/mco2.70182. eCollection 2025 May.
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Case Report: Severe ophiasis-pattern alopecia areata with concomitant atopic dermatitis in a 5-year-old boy successfully treated with dupilumab.病例报告：一名5岁男孩患有严重的ophiasis型斑秃并伴有特应性皮炎，使用度普利尤单抗成功治疗。
Front Pediatr. 2025 Feb 10;13:1517769. doi: 10.3389/fped.2025.1517769. eCollection 2025.
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Healthy individuals genetically at-risk for the development of Pemphigus vulgaris or Alopecia areata share disease-like cytokine dysregulation.在基因上有寻常型天疱疮或斑秃发病风险的健康个体存在类似疾病的细胞因子失调。
Front Immunol. 2025 Jan 13;15:1500284. doi: 10.3389/fimmu.2024.1500284. eCollection 2024.
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Case Report: Baricitinib improved alopecia areata in a pediatric patient with atopic dermatitis.病例报告：巴瑞替尼改善了一名患有特应性皮炎的儿科斑秃患者的病情。
Front Pediatr. 2025 Jan 10;12:1497285. doi: 10.3389/fped.2024.1497285. eCollection 2024.
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Predictors and Management of Inadequate Response to JAK Inhibitors in Alopecia Areata.斑秃对 JAK 抑制剂反应不足的预测因素和管理。
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Exploring the Complexities of Atopic Dermatitis: Pathophysiological Mechanisms and Therapeutic Approaches.探索特应性皮炎的复杂性：病理生理机制与治疗方法
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Arch Dermatol Res. 2024 Jul 23;316(7):487. doi: 10.1007/s00403-024-03225-4.
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Front Immunol. 2024 May 29;15:1405215. doi: 10.3389/fimmu.2024.1405215. eCollection 2024.