脐带血采集在需要复苏的早产儿中的应用：一项随机对照试验。
Umbilical cord milking in preterm neonates requiring resuscitation: A randomized controlled trial.
机构信息
Department of Neonatology, St. John's Medical College Hospital, Bangalore, India.
Department of Neonatology, St. John's Medical College Hospital, Bangalore, India.
出版信息
Resuscitation. 2018 Sep;130:88-91. doi: 10.1016/j.resuscitation.2018.07.003. Epub 2018 Jul 5.
OBJECTIVE
To evaluate the effect of cord milking on short term morbidity and hematologic parameters at 6 weeks in preterm neonates requiring resuscitation.
METHODS
This trial randomized preterm infants requiring resuscitation to milking group and no milking group. Multiple pregnancy, Rh negative mothers, hydrops, cord abnormalities were excluded. The primary outcome was hemoglobin and serum ferritin at 6 weeks of life. Secondary outcomes were common preterm morbidities and mortality.
RESULTS
60 neonates were included in the study. Infants in the milking group had higher hemoglobin (10.07 g/dl vs 8.9 g/dl; p 0.003) and higher serum ferritin level (244.8 ng/ml vs 148.5 ng/ml; p 0.04) compared to no milking group.
CONCLUSIONS
In preterm neonates requiring resuscitation, umbilical cord milking results in higher hemoglobin and ferritin at 6 weeks of life. It can be a used as a placental transfusion strategy in preterm neonates requiring resuscitation with no significant adverse effects.
CLINICAL TRIAL REGISTRATION
Clinical trials registry -India CTRI/2015/01/005436, www.ctri.nic.in.
目的
评估需要复苏的早产儿断脐时挤脐血对 6 周内短期发病率和血液学参数的影响。
方法
本试验将需要复苏的早产儿随机分为挤脐血组和不挤脐血组。排除多胎妊娠、Rh 阴性母亲、水肿、脐带异常。主要结局是出生后 6 周时的血红蛋白和血清铁蛋白。次要结局是常见的早产儿并发症和死亡率。
结果
研究纳入 60 例新生儿。挤脐血组的血红蛋白（10.07g/dl 比 8.9g/dl；p<0.003）和血清铁蛋白水平（244.8ng/ml 比 148.5ng/ml；p=0.04）均高于不挤脐血组。
结论
在需要复苏的早产儿中，断脐时挤脐血可导致出生后 6 周时血红蛋白和铁蛋白升高。在无明显不良反应的情况下，它可以作为需要复苏的早产儿的一种胎盘输血策略。
临床试验注册
印度临床试验注册中心 - CTRI/2015/01/005436，www.ctri.nic.in。
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