Center for Iron Disorders, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, 10833 LeConte Ave, CHS 37-131, Los Angeles, CA 90095, USA.
Free Radic Biol Med. 2019 Mar;133:254-261. doi: 10.1016/j.freeradbiomed.2018.07.001. Epub 2018 Jul 5.
As the interface between the fetal and maternal circulation, the placenta facilitates both nutrient and waste exchange for the developing fetus. Iron is essential for healthy pregnancy, and transport of iron across the placenta is required for fetal growth and development. Perturbation of this transfer can lead to adverse pregnancy outcomes. Despite its importance, our understanding of how a large amount of iron is transported across placental membranes, how this process is regulated, and which iron transporter proteins function in different placental cells remains rudimentary. Mechanistic studies in mouse models, including placenta-specific deletion or overexpression of iron-related proteins will be essential to make progress. This review summarizes our current understanding about iron transport across the syncytiotrophoblast under physiological conditions and identifies areas for further investigation.
作为胎儿和母体循环的界面，胎盘促进了营养物质和废物的交换，为胎儿的发育提供支持。铁对于健康妊娠至关重要，而铁在胎盘内的转运对于胎儿的生长和发育也是必需的。如果这一转运过程受到干扰，可能会导致不良的妊娠结局。尽管其重要性不言而喻，但我们对于大量的铁是如何穿过胎盘膜进行转运的、这一过程是如何被调控的以及哪些铁转运蛋白在不同的胎盘细胞中发挥作用，仍知之甚少。利用包括胎盘特异性敲除或过表达铁相关蛋白的小鼠模型进行的机制研究，对于取得进展至关重要。这篇综述总结了我们目前对于在生理条件下铁穿过合体滋养层转运的理解，并确定了进一步研究的领域。
