Peking University Health Science Center, Beijing, China.
Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, China.
BMC Pregnancy Childbirth. 2024 Oct 18;24(1):677. doi: 10.1186/s12884-024-06832-1.
Neonatal anemia has a long-term effect on children's growth and development. Anemia during pregnancy is also the most widespread nutritional deficiency among pregnant women in the world; If it leads to anemia in newborns, it will affect a wide range of people and be a public health problem worthy of attention.
To study the relationship between maternal anemia during pregnancy and neonatal hemoglobin levels.
PubMed, Web of science, Scopus, MEDLINE, Embase, ProQuest, Dissertations & Theses Global, The Cochrane Library, China Biology Medicine Database, Chinese CNKI Database, and Chinese Wanfang Database were systematically searched from inception to August 31, 2022.
The meta-analysis included all original studies which pertain to cohort studies, case-control studies or cross-sectional studies that investigated the relationship between maternal anemia during pregnancy and neonatal hemoglobin levels.
Hemoglobin level of both anemic and non-anemic pregnant mothers and their paired newborns were pooled from the selected studies. The random-effects model was used to assess the risk of getting a lower neonatal hemoglobin level between mothers with and without pregnant anemia. Data analyses were performed from September 5, 2022, to March 10, 2023.
Maternal anemia during pregnancy is a risk factor of lower neonatal hemoglobin levels.
The initial search yielded 4267 records of which 116 articles underwent full-text evaluation, which identified 18 articles and a total of 1873 patients that were included. The findings of the meta-analysis showed a significant difference between the two groups(MD=-1.38; 95%CI:[-1.96,-0.80]. p<0.01), while the co-effect showed that the neonatal hemoglobin value of anemic mothers was 1.38g/dL lower than that of non-anemic mothers(-1.96,-0.80), suggesting a correlation between maternal anemia lower neonatal hemoglobin levels.
This systematic review and meta-analysis demonstrated that maternal anemia during pregnancy were associated with a lower level of newborn hemoglobin levels. This may enable a better understanding of neonatal anemia and provide guidance towards future development of nutritional supplementation during pregnancy and the prediction of postpartum outcomes.
PROSPERO Identifier: CRD42022352759.
新生儿贫血对儿童的生长发育有长期影响。怀孕期间贫血也是世界范围内孕妇最普遍的营养缺乏症；如果导致新生儿贫血，将影响广泛人群，成为值得关注的公共卫生问题。
研究孕妇怀孕期间贫血与新生儿血红蛋白水平之间的关系。
从建库至 2022 年 8 月 31 日，系统检索了 PubMed、Web of science、Scopus、MEDLINE、Embase、ProQuest、Dissertations & Theses Global、The Cochrane Library、中国生物医学文献数据库、中国知网数据库和中国万方数据库，以获取有关孕妇怀孕期间贫血与新生儿血红蛋白水平之间关系的所有原始研究。
荟萃分析纳入了所有队列研究、病例对照研究或横断面研究，这些研究调查了孕妇怀孕期间贫血与新生儿血红蛋白水平之间的关系。
从选定的研究中提取了患有贫血和非贫血的孕妇及其配对新生儿的血红蛋白水平。使用随机效应模型评估了患有孕妇贫血和不患有孕妇贫血的母亲所生新生儿血红蛋白水平较低的风险。数据分析于 2022 年 9 月 5 日至 2023 年 3 月 10 日进行。
孕妇怀孕期间贫血是新生儿血红蛋白水平较低的一个危险因素。
最初的搜索产生了 4267 条记录，其中 116 篇文章进行了全文评估，确定了 18 篇文章和总共 1873 名患者纳入研究。荟萃分析的结果显示两组之间存在显著差异(MD=-1.38；95%CI：[-1.96，-0.80]。p<0.01)，而共效分析表明，贫血母亲的新生儿血红蛋白值比非贫血母亲低 1.38g/dL(-1.96，-0.80)，提示孕妇贫血与新生儿血红蛋白水平较低之间存在相关性。
本系统评价和荟萃分析表明，孕妇怀孕期间贫血与新生儿血红蛋白水平较低有关。这可能有助于更好地了解新生儿贫血，并为未来的孕期营养补充和产后结局预测提供指导。
PROSPERO 标识符：CRD42022352759。
