Simonyte Sandrita, Kuciene Renata, Dulskiene Virginija, Lesauskaite Vaiva
Institute of Cardiology of the Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
BMJ Open. 2018 Jul 7;8(7):e019902. doi: 10.1136/bmjopen-2017-019902.
Recently, genome-wide associated studies have identified several genetic loci that are associated with elevated blood pressure and could play a critical role in intracellular calcium homeostasis. The aim of this study was to assess the associations of rs2681472 and rs12258967 gene polymorphisms with high blood pressure (HBP) among Lithuanian children and adolescents aged 12-15 years.
This was a cross-sectional study of a randomly selected sample of 646 12-15-year-old adolescents who participated in the survey 'The Prevalence and Risk Factors of HBP in 12-15 Year-Old Lithuanian Children and Adolescents (from November 2010 to April 2012)'. Anthropometric parameters and BP were measured. The participants with HBP were screened on two separate occasions. Subjects were genotyped rs2681472 and rs12258967 gene polymorphisms using real-time PCR method.
The prevalence of HBP was 36.7%, significantly higher for boys than for girls. In the multivariate analysis, after adjustment for body mass index and waist circumference, boys with CG genotype, GG genotype and CG +GG genotype had higher odds of having HBP in codominant (adjusted OR (aOR)=1.92; 95% CI 1.16 to 3.18, p=0.011; and aOR=2.64; 95% CI 1.19 to 5.90, p=0.018) and in dominant (aOR=2.05; 95% CI 1.27 to 3.30, p=0.003) inheritance models. Girls carrying CG genotype and CG +GG genotype had increased odds of HBP in codominant (aOR=1.82; 95% CI 1.02 to 3.24, p=0.044) and in dominant (aOR=1.89; 95% CI 1.09 to 3.28, p=0.023) inheritance models. Furthermore, significant associations were found in additive models separately for boys (aOR=1.72; 95% CI 1.20 to 2.46, p=0.003) and girls (aOR=1.52; 95% CI 1.05 to 2.20, p=0.027). No significant association was found between gene polymorphism and the odds of HBP.
Our results indicate that gene polymorphism was significantly associated with higher odds of HBP in Lithuanian adolescents aged 12-15 years.
最近，全基因组关联研究已经确定了几个与血压升高相关的基因位点，这些位点可能在细胞内钙稳态中起关键作用。本研究的目的是评估rs2681472和rs12258967基因多态性与立陶宛12至15岁儿童和青少年高血压（HBP）之间的关联。
这是一项横断面研究，随机选取了646名12至15岁的青少年作为样本，他们参与了“立陶宛12至15岁儿童和青少年HBP的患病率及危险因素（2010年11月至2012年4月）”的调查。测量了人体测量参数和血压。对患有HBP的参与者在两个不同的时间点进行了筛查。采用实时聚合酶链反应方法对受试者的rs2681472和rs12258967基因多态性进行基因分型。
HBP的患病率为36.7%，男孩显著高于女孩。在多变量分析中，在调整了体重指数和腰围后，携带CG基因型、GG基因型以及CG + GG基因型的男孩在共显性（调整后的比值比（aOR）=1.92；95%置信区间1.16至3.18，p = 0.011；aOR = 2.64；95%置信区间1.19至5.90，p = 0.018）和显性（aOR = 2.05；95%置信区间1.27至3.30，p = 0.003）遗传模型中患HBP的几率更高。携带CG基因型和CG + GG基因型的女孩在共显性（aOR = 1.82；95%置信区间1.02至3.24，p = 0.044）和显性（aOR = 1.89；95%置信区间1.09至3.28，p = 0.023）遗传模型中患HBP的几率增加。此外，在加性模型中分别在男孩（aOR = 1.72；95%置信区间1.20至2.46，p = 0.003）和女孩（aOR = 1.52；95%置信区间1.05至2.20，p = 0.027）中发现了显著关联。未发现基因多态性与HBP几率之间存在显著关联。
我们的结果表明，基因多态性与立陶宛12至15岁青少年患HBP的较高几率显著相关。
