鼻病毒与哮喘恶化。
Rhinovirus and Asthma Exacerbations.
机构信息
Department of Pediatrics, University of Arkansas for Medical Sciences, 13 Children's Way, Slot 512-13, Little Rock, AR 72202, USA; Department of Internal Medicine, University of Arkansas for Medical Sciences, 13 Children's Way, Slot 512-13, Little Rock, AR 72202, USA; Arkansas Children's Research Institute, University of Arkansas for Medical Sciences, 13 Children's Way, Slot 512-13, Little Rock, AR 72202, USA.
Department of Pediatrics, University of Arkansas for Medical Sciences, 13 Children's Way, Slot 512-13, Little Rock, AR 72202, USA.
出版信息
Immunol Allergy Clin North Am. 2019 Aug;39(3):335-344. doi: 10.1016/j.iac.2019.03.003. Epub 2019 May 15.
Rhinovirus (RV) is ubiquitous and typically causes only minor upper respiratory symptoms. However, especially in children and adolescent asthmatics, RV is responsible for most exacerbations. This ability of RV to drive exacerbations typically requires the concomitant presence of exposure to a bystander allergen. Susceptibility to RV-mediated exacerbations is also related to the genetic background of the host, which contributes to greater infectivity, more severe infections, altered immune responses, and to greater inflammation and loss of asthma control. Given these responses, there are several treatments available or being developed that should improve the control of exacerbations related to RV infection.
鼻病毒（RV）无处不在，通常只会引起轻微的上呼吸道症状。然而，尤其是在儿童和青少年哮喘患者中，RV 是大多数哮喘加重的原因。RV 引发哮喘加重的能力通常需要同时接触旁观者过敏原。宿主的遗传背景也与 RV 介导的加重易感性有关，这导致更高的传染性、更严重的感染、改变的免疫反应以及更大的炎症和哮喘控制丧失。鉴于这些反应，有几种现有的或正在开发的治疗方法应该可以改善与 RV 感染相关的加重的控制。
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