一项评估使用不同类型口罩的医护人员静脉血气参数和缺氧生物标志物变化的试点研究。

A pilot study to evaluate the changes in venous blood gas parameters and hypoxia biomarkers in health care workers using different kinds of masks.

作者信息

Patel Suprava, Mohapatra Eli, Suganthy Asha K, Shah Seema, Abraham Jessy, Nanda Rachita, Behera Ajoy K, Gupta Ashish

机构信息

Department of Biochemistry, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India.

Department of Pulmonary Medicine, All India Institute of Medical Sciences, Raipur, Chhattisgarh, India.

出版信息

Lung India. 2023 Mar-Apr;40(2):134-142. doi: 10.4103/lungindia.lungindia_343_22.

DOI:10.4103/lungindia.lungindia_343_22

PMID:37006097

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10174648/

Abstract

BACKGROUND

The study is aimed to investigate the metabolic alterations and changes in biochemical parameters associated with extended mask.

METHODS

It was a prospective comparative study conducted on 129 participants comprised of 37 healthy controls and 92 health care workers using different kind of masks like, cloth mask, surgical masks and N95-FFR/PPE. Two samples on day-1 and day-10 were collected for analysis of blood gas parameters, serum hypoxia-inducible factor-α (HIF-α), and erythropoietin (EPO).

RESULTS

Oxygen saturation percentage (sO) of 72.68 (P = 0.033) was significantly low, whereas, Na (P = 0.05) and Ca (P < 0.001) were raised in exposed individuals than the healthy controls. The serum HIF-α level of 3.26 ng/mL, was considerable higher in the exposed individuals than controls (P = 0.001). pO and sO were the lowest and HIF-α and EPO were raised in N95-FFR/PPE of all mask users (P < 0.01). A significant difference was evidenced for pCO, pH, Na, Ca, and EPO in the exposed group. A positive correlation between the duration of mask use (in hours) with HIF-α (r = 0.247, P = 0.005) and Ca (r = 0.306, P < 0.001) was observed. The major complaints in N95-FFR/PPE users were headache (15.2%) and polydipsia (33.3%).

CONCLUSION

The study findings depicted a significant metabolic alterations in PPE/N95 users which could be due to chronic hypoxic exposure of the tissues.

摘要

背景

本研究旨在调查与长时间佩戴口罩相关的代谢改变和生化参数变化。

方法

这是一项前瞻性比较研究，对129名参与者进行了研究，其中包括37名健康对照者和92名医护人员，他们使用了不同类型的口罩，如布口罩、外科口罩和N95-FFR/PPE。在第1天和第10天采集两份样本，用于分析血气参数、血清缺氧诱导因子-α（HIF-α）和促红细胞生成素（EPO）。

结果

暴露个体的氧饱和度百分比（sO）为72.68（P = 0.033），显著低于健康对照者，而钠（P = 0.05）和钙（P < 0.001）则高于健康对照者。暴露个体的血清HIF-α水平为3.26 ng/mL，显著高于对照组（P = 0.001）。在所有口罩使用者中，N95-FFR/PPE组的pO和sO最低，HIF-α和EPO升高（P < 0.01）。暴露组的pCO、pH、钠、钙和EPO存在显著差异。观察到口罩使用时间（小时）与HIF-α（r = 0.247，P = 0.005）和钙（r = 0.306，P < 0.001）之间存在正相关。N95-FFR/PPE使用者的主要抱怨是头痛（15.2%）和多饮（33.3%）。