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原发性中枢神经系统淋巴瘤患者治疗过程中脑脊液中新喋呤的诊断作用及动态变化。

The diagnostic role and dynamic changes in cerebrospinal fluid neopterin during treatment of patients with primary central nervous system lymphoma.

机构信息

Cancer Center, Institute of Surgery Research, Third Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, China.

Department of Clinical Laboratory, Institute of Surgery Research, Third Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, China.

出版信息

Cancer Med. 2018 Aug;7(8):3889-3898. doi: 10.1002/cam4.1581. Epub 2018 Jul 7.

DOI:10.1002/cam4.1581
PMID:29982995
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6089159/
Abstract

This study aimed at evaluating the diagnostic and prognostic role of neopterin (Npt) concentration in the cerebrospinal fluid (CSF) of patients with primary central nervous system lymphoma (PCNSL). Ninety-nine patients were enrolled in this retrospective study; these included patients with PCNSL (n = 21), other brain tumors (n = 44), and inflammatory diseases (n = 34). CSF Npt concentration was measured using ELISA. Receiver operating characteristic (ROC) curve analysis was performed to assess the discriminative ability of CSF Npt concentration for the diagnosis of PCNSL. CSF Npt concentration in patients with PCNSL was significantly higher than that in patients with other brain tumors and inflammatory diseases (P < .001). On ROC curve analysis, the optimal cutoff CSF Npt level of 10.77 ng/mL for the diagnosis of PCNSL and the diagnostic yield of MRI were increased when used in conjunction with CSF Npt concentration. The CSF Npt concentrations in PCNSL patients with multiple lesions were significantly higher than those in patients with a single lesion. Changes in CSF Npt concentration were consistent with post-treatment changes in tumor sizes. The CSF Npt concentration may be a good biomarker for the diagnosis, for monitoring of disease course, and for prognostic evaluation of patients with PCNSL.

摘要

本研究旨在评估新型蝶呤（Npt）在原发性中枢神经系统淋巴瘤（PCNSL）患者脑脊液（CSF）中的诊断和预后作用。本回顾性研究纳入了 99 名患者；其中包括 PCNSL 患者（n=21）、其他脑肿瘤患者（n=44）和炎症性疾病患者（n=34）。采用 ELISA 法测定 CSF Npt 浓度。通过接收者操作特征（ROC）曲线分析评估 CSF Npt 浓度对 PCNSL 诊断的区分能力。PCNSL 患者的 CSF Npt 浓度明显高于其他脑肿瘤和炎症性疾病患者（P<.001）。在 ROC 曲线分析中，当联合 CSF Npt 浓度使用时，诊断 PCNSL 的最佳 CSF Npt 截断值为 10.77ng/mL，MRI 的诊断率提高。多发性病变 PCNSL 患者的 CSF Npt 浓度明显高于单发病变患者。CSF Npt 浓度的变化与肿瘤大小的治疗后变化一致。CSF Npt 浓度可能是 PCNSL 患者诊断、监测疾病进程和预后评估的良好生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd24/6089159/f11bb9696eb9/CAM4-7-3889-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd24/6089159/900374aabfb9/CAM4-7-3889-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd24/6089159/f11bb9696eb9/CAM4-7-3889-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd24/6089159/900374aabfb9/CAM4-7-3889-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dd24/6089159/f11bb9696eb9/CAM4-7-3889-g002.jpg

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