Alemu Aynadis, Abebe Molla, Biadgo Belete, Terefe Betelihem, Baynes Habtamu Wondifraw
Department of Clinical Chemistry, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Northwest Ethiopia.
Department of Hematology, School of Biomedical and Laboratory Sciences, College of Medicine and Health Sciences, University of Gondar, Northwest Ethiopia.
Ethiop J Health Sci. 2018 May;28(3):331-340. doi: 10.4314/ejhs.v28i3.11.
Pregnancy is a natural physiological statement with hormonal and metabolic changes that helps the growth and survival of the fetus. However, biochemical profiles derangement may lead to pregnancy complications. Therefore, there is a need for determining biochemical profiles among pregnant women.
A comparative cross-sectional study was conducted among pregnant and non-pregnant women at the University of Gondar Hospital, from February to April, 2015. Fasting blood sample was collected from 139 pregnant and 139 age matched non-pregnant women using systematic random sampling technique. Interviewer-administered questionnaire was used to collect socio-demographic and clinical data. Fasting blood glucose and lipid profile were measured by A25 Biosytemchemistry analyzer using enzymatic calorimetric methods. Data analysis was done using SPSS version 20. Level of significance between groups was analyzed using independent student t-test and Mann-Whitney U test. A p-value of <0.05 was considered as statistically significant.
Pregnant women as compared to non-pregnant had significantly increased glucose (96.35±14.45 and 81.12±9.86 mg/dl), total cholesterol (211.9±40.88 and 172.40±29.64 mg/dl) [p<0.05], respectively. It had also significantly high triglycerides (190.81±81.04 and 107.43±45.80 mg/dl) and low-density lipoprotein cholesterol (116.03±37.26 and 86.12±27.29mg/dl) [p<05] in pregnant as compared to non-pregnant women. The level of high-density lipoprotein cholesterol was significantly lower in pregnant women (59.58±14.26) than control (63.63±11.4, P <0.05).
There were statistically significant increment in glucose, total cholesterol, triglycerides, low-density lipoprotein cholesterol and decrement in high-density lipoprote in cholesterol levels among pregnant women compared with non-pregnant women. Therefore, pregnant women have to be monitored closely for their biochemical profiles to avoid adverse pregnancy outcomes.
怀孕是一种自然的生理状态，伴随着激素和代谢变化，有助于胎儿的生长和存活。然而，生化指标紊乱可能导致妊娠并发症。因此，有必要测定孕妇的生化指标。
2015年2月至4月，在贡德尔大学医院对孕妇和非孕妇进行了一项比较横断面研究。采用系统随机抽样技术，从139名孕妇和139名年龄匹配的非孕妇中采集空腹血样。通过访谈者管理的问卷收集社会人口学和临床数据。使用A25生化分析仪采用酶比色法测量空腹血糖和血脂谱。使用SPSS 20版进行数据分析。使用独立样本t检验和曼-惠特尼U检验分析组间的显著性水平。p值<0.05被认为具有统计学意义。
与非孕妇相比，孕妇的血糖（分别为96.35±14.45和81.12±9.86mg/dl）、总胆固醇（分别为211.9±40.88和172.40±29.64mg/dl）[p<0.05]显著升高。与非孕妇相比，孕妇的甘油三酯（分别为190.81±81.04和107.43±45.80mg/dl）和低密度脂蛋白胆固醇（分别为116.03±37.26和86.12±27.29mg/dl）[p<0.05]也显著升高。孕妇的高密度脂蛋白胆固醇水平（59.58±14.26）显著低于对照组（63.63±11.4，P<0.05）。
与非孕妇相比，孕妇的血糖、总胆固醇、甘油三酯、低密度脂蛋白胆固醇水平有统计学意义的升高，高密度脂蛋白胆固醇水平有统计学意义的降低。因此，必须密切监测孕妇的生化指标，以避免不良妊娠结局。
