Alemu Aynadis, Abebe Molla, Terefe Betelihem, Yesuf Mohammed, Melku Mulugeta, Enawgaw Bamlaku, Biadgo Belete
Clin Lab. 2019 Aug 1;65(8). doi: 10.7754/Clin.Lab.2019.190115.
Pregnancy is a natural physiological variation as a result of hormonal and metabolic changes. Worldwide a large proportion of women are expected to die each year as a result of pregnancy complication related to hematological profile alterations. Therefore, this study is aimed at assessing hematological indices of pregnant in comparison with non-pregnant women.
A comparative cross-sectional study was conducted among pregnant and non-pregnant women at the University of Gondar Hospital, from February to April 2015. A blood sample was collected from 139 pregnant and 139 age-matched non-pregnant women using systematic random sampling technique. Data analysis was made using SPSS version 20. Level of significance was analyzed using independent t-test and Mann-Whitney U test. A p-value ≤ 0.05 was considered statistically significant.
In this study, pregnant women had significantly higher WBC count [(7.08 ± 2.07 vs. 5.77 ± 1.85) x 109/L], MCV [(93.16 ± 3.44 vs. 90.74 ± 4.12) fL], MCHC [(30.40 ± 1.19 vs. 29.47 ± 1.46) pg], Neutrophil count [(4.73 ± 1.86 vs. 3.06 ± 1.47) x 109/L], Lymphocyte count [(1.65 ± 0.41 vs. 1.2 ± 0.54) x 109/L], RDW [(49.35 ± 2.9 vs. 46.37 ± 2.73) fL], PDW [(14.02 ± 0.6 vs. 13.12 ± 0.19) fL], and MPV [(10.49 ± 0.95 vs. 10.06 ± 1.18) fL] compared with controls. The RBC count [(4.55 ± 0.38 vs. 5.14 ± 0.53) x 1012/L], Hb [(13.73 ± 0.96 vs. 15.30 ± 1.074) g/dL], Hct [(42.14 ± 2.55 vs. 47.16 ± 3.36)%], and Platelets [(196.07 ± 48.88 vs. 249.36 ± 62.73) x 109/L] were significantly lower among pregnant women compared to the control group, respectively. This study also indicated that there was a significant difference in MCV, MCH, platelet count, absolute lymphocyte count and RDW across the three trimes-ters of pregnancy.
This study found a statistically significant difference in the majority of hematological indices between pregnant and non-pregnant women. Trimesters of pregnancy have an influence on some hematological indices. This study provides baseline data for basic hematological indices changes, and it is vital especially in the antenatal care assessment to avoid pregnancy-related adverse outcomes.
怀孕是激素和代谢变化导致的自然生理变异。在全球范围内，预计每年有很大比例的女性因与血液学指标改变相关的妊娠并发症而死亡。因此，本研究旨在评估孕妇与非孕妇的血液学指标。
2015年2月至4月，在贡德尔大学医院对孕妇和非孕妇进行了一项比较横断面研究。采用系统随机抽样技术，从139名孕妇和139名年龄匹配的非孕妇中采集血样。使用SPSS 20版进行数据分析。采用独立t检验和曼-惠特尼U检验分析显著性水平。p值≤0.05被认为具有统计学意义。
在本研究中，与对照组相比，孕妇的白细胞计数[(7.08±2.07对5.77±1.85)×10⁹/L]、平均红细胞体积[(93.16±3.44对90.74±4.12)fL]、平均血红蛋白浓度[(30.40±1.19对29.47±1.46)pg]、中性粒细胞计数[(4.73±1.86对3.06±1.47)×10⁹/L]、淋巴细胞计数[(1.65±0.41对1.2±0.54)×10⁹/L]、红细胞分布宽度[(49.35±2.9对46.37±2.73)fL]、血小板分布宽度[(14.02±0.6对13.12±0.19)fL]和平均血小板体积[(10.49±0.95对10.06±1.18)fL]显著更高。孕妇的红细胞计数[(4.55±0.38对5.14±0.53)×10¹²/L]、血红蛋白[(13.73±0.96对15.30±1.074)g/dL]、血细胞比容[(42.14±2.55对47.16±3.36)%]和血小板[(196.07±48.88对249.36±62.73)×10⁹/L]分别显著低于对照组。本研究还表明，妊娠三个阶段的平均红细胞体积、平均红细胞血红蛋白含量、血小板计数、绝对淋巴细胞计数和红细胞分布宽度存在显著差异。
本研究发现孕妇与非孕妇在大多数血液学指标上存在统计学显著差异。妊娠阶段对一些血液学指标有影响。本研究提供了基本血液学指标变化的基线数据，这在产前护理评估中尤为重要，以避免与妊娠相关的不良结局。
