Isler Sila Cagri, Unsal Berrin, Soysal Fatma, Ozcan Gonen, Peker Elif, Karaca Inci Rana
Department of Periodontology, Gazi University Faculty of Dentistry, Ankara, Turkey.
Department of Oral and Maxillofacial Surgery, Gazi University Faculty of Dentistry, Ankara, Turkey.
J Periodontal Implant Sci. 2018 Jun 30;48(3):136-151. doi: 10.5051/jpis.2018.48.3.136. eCollection 2018 Jun.
The decontamination procedure is a challenging aspect of surgical regenerative therapy (SRT) of peri-implantitis that affects its success. The purpose of the present study was to determine the impact of additional topical gaseous ozone therapy on the decontamination of implant surfaces in SRT of peri-implantitis.
A total of 41 patients (22 males, 19 females; mean age, 53.55±8.98 years) with moderate or advanced peri-implantitis were randomly allocated to the test group (ozone group) with the use of sterile saline with additional ozone therapy or the control group with sterile saline alone for decontamination of the implant surfaces in SRT of peri-implantitis. Clinical and radiographic outcomes were evaluated over a period of 12 months.
At the 12-month follow-up, the plaque and gingival index values were significantly better in the ozone group (<0.05). Probing depth decreased from 6.27±1.42 mm and 5.73±1.11 mm at baseline to 2.75±0.7 mm and 3.34±0.85 mm at the end of the 12-month observation period in the ozone and control groups, respectively. Similarly, the clinical attachment level values changed from 6.39±1.23 mm and 5.89±1.23 mm at baseline to 3.23±1.24 mm and 3.91±1.36 mm at the 12-month follow-up in the ozone and control groups, respectively. According to the radiographic evidence, the defect fill between baseline and 12 months postoperatively was 2.32±1.28 mm in the ozone group and 1.17±0.77 mm in the control group, which was a statistically significant between-group difference (<0.05).
Implant surface decontamination with the additional use of ozone therapy in SRT of peri-implantitis showed clinically and radiographically significant. Trial registry at ClinicalTrials.gov, NCT03018795.
去污程序是种植体周围炎外科再生治疗（SRT）中具有挑战性的一个方面，会影响其成功率。本研究的目的是确定额外的局部气态臭氧疗法对种植体周围炎SRT中种植体表面去污的影响。
总共41例中度或重度种植体周围炎患者（22例男性，19例女性；平均年龄53.55±8.98岁）被随机分配到试验组（臭氧组），在种植体周围炎SRT中使用添加臭氧疗法的无菌盐水进行种植体表面去污，或分配到对照组，仅使用无菌盐水。在12个月的时间里评估临床和影像学结果。
在12个月的随访中，臭氧组的菌斑和牙龈指数值明显更好（<0.05）。在臭氧组和对照组中，探诊深度在12个月观察期结束时分别从基线时的6.27±1.42mm和5.73±1.11mm降至2.75±0.7mm和3.34±0.85mm。同样，临床附着水平值在臭氧组和对照组中分别从基线时的6.39±1.23mm和5.89±1.23mm在12个月随访时变为3.23±1.24mm和3.91±1.36mm。根据影像学证据，臭氧组术后基线至12个月的缺损填充为2.32±1.28mm，对照组为1.17±0.77mm，组间差异有统计学意义（<0.05）。
在种植体周围炎SRT中额外使用臭氧疗法进行种植体表面去污在临床和影像学上均显示出显著效果。试验注册于ClinicalTrials.gov，NCT03018795。
