Shaw P J, Bates D, Cartlidge N E, Heaviside D, Julian D G, Shaw D A
Br Med J (Clin Res Ed). 1985 Nov 16;291(6506):1384-7. doi: 10.1136/bmj.291.6506.1384.
A prospective study of 312 patients undergoing elective coronary artery bypass surgery was undertaken to determine the incidence, severity, and functional impact of postoperative neurological complications. Detailed evaluation of the patients showed that neurological complications after surgery were common, occurring in 191 of the 312 patients (61%). Although such a high proportion of the total developed detectable changes, serious neurological morbidity was rare. Neurological disorders resulted in death in only one patient (0.3%) and severe disability in only four (1.3%). Forty eight patients were mildly disabled during the early postoperative period, and the remaining 138 with neurological signs had no serious functional disability. The postoperative neurological disorders detected included one death from cerebral hypoxic damage. Prolonged depression of conscious level was observed in 10 patients (3%) and definite stroke in 15 (5%); 78 (25%) developed ophthalmological abnormalities and 123 (39%) primitive reflexes; postoperative psychosis was observed in four (1%); and 37 (12%) developed disorders of the peripheral nervous system. The incidence of serious neurological problems such as fatal cerebral damage, stroke, and brachial plexopathy is in accordance with experience elsewhere. Lesser abnormalities, whose detection required detailed neurological examination, were much commoner than expected from previous reports.
对312例行择期冠状动脉搭桥手术的患者进行了一项前瞻性研究,以确定术后神经并发症的发生率、严重程度及功能影响。对患者的详细评估显示,术后神经并发症很常见,312例患者中有191例(61%)出现此类并发症。尽管在所有出现可检测到变化的患者中这一比例很高,但严重的神经病变很少见。神经功能障碍仅导致1例患者死亡(0.3%),4例严重残疾(1.3%)。48例患者在术后早期有轻度残疾,其余138例有神经体征者无严重功能残疾。检测到的术后神经功能障碍包括1例因脑缺氧损伤死亡。10例患者(3%)出现意识水平长时间下降,15例(5%)发生明确的中风;78例(25%)出现眼科异常,123例(39%)出现原始反射;4例(1%)出现术后精神错乱;37例(12%)出现周围神经系统疾病。严重神经问题如致命性脑损伤、中风和臂丛神经病变的发生率与其他地方的经验相符。需要详细神经检查才能检测到的较轻异常比以往报告预期的更为常见。