利用带有堆积单元的亲水性聚合物的疏水药物传递的新策略。
A new strategy for hydrophobic drug delivery using a hydrophilic polymer equipped with stacking units.
机构信息
State Key Laboratory of Natural Medicines, Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China.
出版信息
Chem Commun (Camb). 2018 Jul 19;54(59):8218-8221. doi: 10.1039/c8cc04363a.
PMID:29985496
Abstract
A highly hydrophilic polymer equipped with guanidinium groups was used to load aromatic ring-containing hydrophobic agent doxorubicin (DOX) via π-π interaction. The results have shown that the delivery system exhibited enhanced cellular uptake and antitumor efficiency compared with free drugs. This study opens new avenues for the application of hydrophilic polymers in drug delivery.
摘要
一种高度亲水的聚合物，其带有胍基，通过π-π 相互作用来装载含有芳环的疏水性药物阿霉素（DOX）。结果表明，与游离药物相比，该递药系统表现出增强的细胞摄取和抗肿瘤效率。这项研究为亲水聚合物在药物传递中的应用开辟了新的途径。
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