School of Electromechanical Engineering, Guangdong University of Technology, Guangzhou 510006, People's Republic of China.
School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, People's Republic of China.
J Mech Behav Biomed Mater. 2018 Oct;86:215-223. doi: 10.1016/j.jmbbm.2018.06.036. Epub 2018 Jun 28.
β-tricalcium phosphate (β-TCP) bioceramic, which is a prevalent bone graft, is deficient in mechanical strength and mediating the biological functions. In the present study, β-tricalcium phosphate composite bioceramics (TCP/SPNs) were prepared by introducing SrO-PO-NaO based (SPN) sintering additive. With increasing mole ratio of SrO to PO, the SPN tended to crystallize. In the liquid-phase sintering process, β-TCP reacted with SPN, producing new compounds. The difference in characteristic of SPN additive affected the compressive strength and cell-biological response of the fabricated TCP/SPNs. By selecting SPN with appropriate formulation, the TCP/SPNs not only could more than double their compressive strength, but also improved the cell viability, promoted osteogenic differentiation and inhibited osteoclastic activities. Taken together, this work establishes a beneficial strategy to improve the overall performance of calcium phosphate bioceramic for application in bone regeneration.
β-磷酸三钙（β-TCP）生物陶瓷是一种常用的骨移植材料，但它的机械强度不足，并且对生物功能的调节作用有限。在本研究中，通过引入 SrO-PO-NaO 基（SPN）烧结添加剂，制备了β-磷酸三钙复合生物陶瓷（TCP/SPNs）。随着 SrO 与 PO 摩尔比的增加，SPN 趋于结晶。在液相烧结过程中，β-TCP 与 SPN 反应，生成新的化合物。SPN 添加剂特性的差异影响了所制备的 TCP/SPNs 的抗压强度和细胞生物学反应。通过选择具有适当配方的 SPN，TCP/SPNs 不仅可以将其抗压强度提高一倍以上，而且还可以提高细胞活力，促进成骨分化并抑制破骨细胞活性。综上所述，这项工作为改善磷酸钙生物陶瓷的整体性能以应用于骨再生提供了一种有益的策略。
