School of Electromechanical Engineering, Guangdong University of Technology, Guangzhou 510006, People's Republic of China; Jihua Laboratory, Foshan 528200, People's Republic of China.
School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, People's Republic of China.
Mater Sci Eng C Mater Biol Appl. 2020 Jul;112:110892. doi: 10.1016/j.msec.2020.110892. Epub 2020 Mar 21.
Magnesium and strontium are able to enhance osteogenesis and suppress osteoclastic activities simultaneously, and they were nontoxic in wide concentration ranges; these make the magnesium-strontium phosphate bioceramics suitable for treating osteoporotic bone defects. The aim of this study was to investigate the effects of strontium amount on the mechanical strength and cell-biological performance of magnesium-strontium phosphate [MgSr(PO); 3-x = 0, 0.1, 0.25, 0.5, 0.75, 1] bioceramics, which were sintered at 1100 °C. The results indicated that the magnesium-strontium phosphate bioceramics except MgSr(PO) and MgSr(PO) bioceramics had considerable compressive strength. The variation in magnesium and strontium contents did not regularly affect the in vitro osteogenic differentiation and osteoclastic activities. The MgSr(PO) bioceramic had the most desirable overall performance, as reflected by considerably high compressive strength, enhanced in vitro osteogenesis and inhibited osteoclastic activities. Therefore, the MgSr(PO) bioceramic is considered a promising biomaterial for osteoporotic bone regeneration.
镁和锶同时具有促进成骨和抑制破骨细胞活性的作用，而且在较宽的浓度范围内没有毒性，这使得镁锶磷酸盐生物陶瓷适合治疗骨质疏松性骨缺损。本研究旨在探讨锶含量对在 1100°C 烧结的镁锶磷酸盐[MgSr(PO);3-x=0、0.1、0.25、0.5、0.75、1]生物陶瓷的力学性能和细胞生物学性能的影响。结果表明，除了 MgSr(PO)和 MgSr(PO)生物陶瓷外，其余的镁锶磷酸盐生物陶瓷都具有相当高的抗压强度。镁和锶含量的变化并不规律地影响体外成骨分化和破骨细胞活性。MgSr(PO)生物陶瓷具有最佳的整体性能，表现为较高的抗压强度、增强的体外成骨和抑制破骨细胞活性。因此，MgSr(PO)生物陶瓷被认为是一种有前途的骨质疏松性骨再生生物材料。
