Department of Clinical Science, Faculty of Medicine, University of Bergen, 5020 Bergen, Norway.
Center for Disease Burden, Norwegian Institute of Public Health, 5020 Bergen, Norway.
Nutrients. 2018 Jul 6;10(7):873. doi: 10.3390/nu10070873.
Hip fractures have a high prevalence worldwide. Few studies have investigated whether fish consumption is associated with risk of hip fractures. The objective of the present study was to investigate the effect of fish intake on the subsequent risk of a hip fracture because of the low number of studies on this topic. A community-based prospective cohort study of 2865 men and women from Hordaland county in Norway, born between 1925⁻1927 and enrolled in the study in 1997⁻1999. Information on hip fracture cases was extracted from hospital records until 31 December 2009. Baseline information on the intake of fish was obtained from a semi-quantitative food frequency questionnaire. Cox proportional hazard regression models with death as a competing risk were used to evaluate the association of fish intake with risk of hip fracture. During a mean (SD) follow-up time of 9.6 (2.7) years, 226 hip fractures (72 in men, 154 in women) were observed. The mean (SD) fish intake was 48 (25) g/1000 kcal. The association between fish intake and risk of hip fracture was not linear and displayed a threshold, with low intake of fish being associated with an increased risk of hip fracture in men (HR (Hazard Ratio) = 1.84, 95% CI 1.10, 3.08). In this community-based prospective study of men and women, a low intake of fish was associated with the risk of a hip fracture in men.
髋部骨折在全球范围内高发。很少有研究调查鱼类摄入与髋部骨折风险之间的关系。本研究的目的是调查鱼类摄入对随后髋部骨折风险的影响，因为关于这个主题的研究数量较少。这是一项基于社区的前瞻性队列研究，纳入了来自挪威霍达兰郡的 2865 名男性和女性，他们出生于 1925-1927 年，并于 1997-1999 年参加了该研究。通过医院记录提取髋部骨折病例的信息，直至 2009 年 12 月 31 日。通过半定量食物频率问卷获取鱼类摄入的基线信息。使用以死亡为竞争风险的 Cox 比例风险回归模型评估鱼类摄入与髋部骨折风险的关系。在平均（标准差）9.6（2.7）年的随访期间，观察到 226 例髋部骨折（男性 72 例，女性 154 例）。鱼类摄入的平均值（标准差）为 48（25）g/1000 千卡。鱼类摄入与髋部骨折风险之间的关系是非线性的，呈现出一个阈值，男性鱼类摄入低与髋部骨折风险增加相关（HR（风险比）=1.84，95%CI 1.10，3.08）。在这项针对男性和女性的基于社区的前瞻性研究中，低鱼类摄入与男性髋部骨折风险相关。
