饮酒与髋部骨折风险之间的关联因年龄和性别而异：挪威队列研究（NOREPOS 研究）。
The association between alcohol consumption and risk of hip fracture differs by age and gender in Cohort of Norway: a NOREPOS study.
机构信息
Division of Mental and Physical Health, Norwegian Institute of Public Health, P.O. Box 4404, 0403, Oslo, Norway.
Department of Clinical Science, University of Bergen, Bergen, Norway.
出版信息
Osteoporos Int. 2018 Nov;29(11):2457-2467. doi: 10.1007/s00198-018-4627-1. Epub 2018 Jul 13.
UNLABELLED
The association between alcohol consumption and hip fracture differed by gender: Men aged 30-59 years drinking frequently or 14+ gl/week had higher risk than moderate drinkers. No significant association was seen in older men. Women not drinking alcohol had higher risk than those drinking moderately both regarding frequency and amount.
INTRODUCTION
We aimed to examine alcohol consumption and risk of hip fracture according to age and gender in the population-based Cohort of Norway (1994-2003).
METHODS
Socio-demographics, lifestyle, and health were self-reported and weight and height were measured in 70,568 men and 71,357 women ≥ 30 years. Information on subsequent hip fractures was retrieved from hospitals' electronic patient registries during 1994-2013. Frequency of alcohol consumption was categorized: never/seldom, moderate (≤ 2-3 times/week), or frequent (≥ 4 times/week), and amount as number of glasses per week: 0, 1-6, 7-13, 14-27, and 28+. Type of alcohol (wine vs. beer/hard liquor) was also examined. Cox's proportional hazards regression was used to estimate hazard ratios (HRs) stratified on gender and baseline age < 60 and ≥ 60 years.
RESULTS
During median 15-year follow-up, 1558 men and 2511 women suffered a hip fracture. Using moderate drinkers as reference, men < 60 years drinking frequently had multivariable adjusted HR = 1.73 (CI 1.02-2.96) for hip fracture and more than 2.5 times higher risk if they consumed 14+ glasses compared to 1-6 glasses per week. In other groups of age and gender, no statistically significant increased risk was found in those consuming the highest levels of alcohol. Compared to women with moderate or frequent alcohol use, never/seldom-drinking women had the highest fracture risk. In women, use of wine was associated with lower fracture risk than other types of alcohol.
CONCLUSIONS
Risk of hip fracture was highest in men < 60 years with the highest frequency and amount of alcohol consumption and in non-drinking women.
未注明
酒精摄入与髋部骨折的关联因性别而异：30-59 岁男性中，频繁饮酒或每周 14 杯以上者比中度饮酒者风险更高。在年龄较大的男性中，未发现显著相关性。不饮酒的女性比适度饮酒的女性髋部骨折风险更高，无论饮酒频率如何。
引言
我们旨在根据年龄和性别，在基于人群的挪威队列研究（1994-2003 年）中，检查酒精摄入与髋部骨折的关系。
方法
社会人口统计学、生活方式和健康状况由自我报告，体重和身高由 70568 名男性和 71357 名≥30 岁的女性测量。1994-2013 年期间，通过医院电子患者登记处检索后续髋部骨折信息。饮酒频率分为：从不/很少、中度（≤2-3 次/周）或频繁（≥4 次/周），每周饮酒量为玻璃杯数：0、1-6、7-13、14-27 和 28+。还检查了酒精的类型（葡萄酒与啤酒/烈性酒）。Cox 比例风险回归用于估计按性别和基线年龄<60 岁和≥60 岁分层的危险比（HRs）。
结果
在中位 15 年随访期间，1558 名男性和 2511 名女性发生髋部骨折。以中度饮酒者为参照，60 岁以下男性频繁饮酒者髋部骨折的多变量调整 HR=1.73（95%CI1.02-2.96），每周饮用 14 杯以上者的风险比更高，是每周饮用 1-6 杯者的 2.5 倍以上。在其他年龄和性别组中，未发现最高饮酒水平的饮酒者有统计学意义上的风险增加。与中度或频繁饮酒的女性相比，从不/很少饮酒的女性骨折风险最高。在女性中，与其他类型的酒精相比，饮用葡萄酒与较低的骨折风险相关。
结论
在 60 岁以下男性中，最高的饮酒频率和饮酒量与髋部骨折风险最高，从不/很少饮酒的女性风险最高。
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