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在体外感染爱泼斯坦-巴尔病毒后，在年轻人、儿童和新生儿中检测到自身反应性B淋巴细胞。

Self-reactive B lymphocytes detected in young adults, children and newborns after in vitro infection with Epstein-Barr virus.

作者信息

Uhlig H, Rutter G, Dernick R

出版信息

Clin Exp Immunol. 1985 Oct;62(1):75-84.

PMID:2998660
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1577419/
Abstract

B-lymphocytes from healthy children and young adults who were seronegative for autoantibodies and B lymphocytes from umbilical cord blood of newborns were induced to secrete a variety of autoantibodies upon infection with Epstein-Barr virus. Such autoantibody-secreting clones were obtained from different lymphoid tissues and occurred at frequencies of 1 in 10(6)-10(7) mononuclear cells. The autoantibodies were exclusively of the IgM class. They recognized normal cellular components, such as cytoplasmic, nuclear and cytoskeletal antigens. The fact that self-reactive clones were not efficiently eliminated during ontogeny suggests that suppressor mechanisms might be responsible for normal self tolerance.

摘要

来自自身抗体血清阴性的健康儿童和年轻成年人的B淋巴细胞以及新生儿脐带血中的B淋巴细胞在感染爱泼斯坦-巴尔病毒后被诱导分泌多种自身抗体。此类分泌自身抗体的克隆是从不同淋巴组织中获得的，在每10(6)-10(7)个单核细胞中的出现频率为1。这些自身抗体均为IgM类。它们识别正常细胞成分，如细胞质、细胞核和细胞骨架抗原。自身反应性克隆在个体发育过程中未被有效清除这一事实表明，抑制机制可能是正常自身耐受的原因。

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Clin Exp Immunol. 1985 Oct;62(1):75-84.
2
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本文引用的文献

1
An absolute method for protein determination based on difference in absorbance at 235 and 280 nm.一种基于235nm和280nm处吸光度差异的蛋白质测定绝对方法。
Anal Biochem. 1980 Nov 15;109(1):156-9. doi: 10.1016/0003-2697(80)90024-x.
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A dot-immunobinding assay for monoclonal and other antibodies.一种用于单克隆抗体及其他抗体的斑点免疫结合测定法。
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Self-stimulating growth factor production by B-cell lines derived from Burkitt's lymphomas and other lines transformed in vitro by Epstein-Barr virus.源自伯基特淋巴瘤的B细胞系以及其他经爱泼斯坦-巴尔病毒体外转化的细胞系的自我刺激生长因子产生。
Cancer Res. 1983 Oct;43(10):4562-8.
7
Efficient generation in vitro, from human peripheral blood cells, of monoclonal Epstein-Barr virus transformants producing specific antibody to a variety of antigens without prior deliberate immunization.无需事先特意免疫，就能从人外周血细胞高效体外生成产生针对多种抗原的特异性抗体的单克隆爱泼斯坦-巴尔病毒转化体。
Proc Natl Acad Sci U S A. 1983 Jul;80(14):4484-8. doi: 10.1073/pnas.80.14.4484.
8
Limiting dilution analysis of Epstein-Barr virus-induced immunoglobulin production.爱泼斯坦-巴尔病毒诱导的免疫球蛋白产生的有限稀释分析
Cell Immunol. 1983 Jul 15;79(2):309-19. doi: 10.1016/0008-8749(83)90073-4.
9
Patterns of isotype commitment in human B cells: limiting dilution analysis of Epstein Barr virus-infected cells.人类B细胞中的同种型定向模式：对爱泼斯坦-巴尔病毒感染细胞的有限稀释分析
J Immunol. 1983 Apr;130(4):1640-5.
10
Polyclonal B-cell activators in the study of the regulation of immunoglobulin synthesis in the human system.人免疫系统中免疫球蛋白合成调节研究中的多克隆B细胞激活剂。
Adv Immunol. 1982;32:1-63. doi: 10.1016/s0065-2776(08)60720-8.