Department of Hematology, First Affiliated Hospital, Institute of Hematology, School of Medicine; Key Laboratory for Regenerative Medicine of Ministry of Education, Jinan University, No.601 West of Huangpu Avenue, Guangzhou, 510632, China.
Department of clinical laboratory, First Affiliated Hospital, Jinan University, Guangzhou, 510632, China.
J Hematol Oncol. 2018 Jul 9;11(1):93. doi: 10.1186/s13045-018-0636-y.
Stem cell memory T (T) and central memory T (T) cells can rapidly differentiate into effector memory (T) and terminal effector (T) T cells, and have the most potential for immunotherapy. In this study, we found that the frequency of T and T cells in the CD8+ population dramatically decreased together with increases in T and T cells, particularly in younger patients with acute myeloid leukemia (AML) (< 60 years). These alterations persisted in patients who achieved complete remission after chemotherapy. The decrease in T and T together with the increase in differentiated T and T subsets in CD8+ T cells may explain the reduced T cell response and subdued anti-leukemia capacity in AML patients.
干细胞记忆 T (T) 和中央记忆 T (T) 细胞可迅速分化为效应记忆 (T) 和终末效应 (T) T 细胞，并且在免疫治疗方面具有最大的潜力。在这项研究中，我们发现 CD8+ 群体中的 T 和 T 细胞的频率与 T 和 T 细胞的增加一起急剧下降，尤其是在年轻的急性髓细胞白血病 (AML) 患者中（<60 岁）。这些改变在化疗后达到完全缓解的患者中仍然存在。CD8+ T 细胞中 T 和 T 的减少以及分化的 T 和 T 亚群的增加可能解释了 AML 患者 T 细胞反应降低和抗白血病能力减弱的原因。
