植物中的 TOR 信号转导：保守与创新。
TOR signaling in plants: conservation and innovation.
机构信息
Department of Molecular Biology and Centre for Computational and Integrative Biology, Massachusetts General Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02114, USA.
Department of Molecular Biology and Centre for Computational and Integrative Biology, Massachusetts General Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02114, USA
出版信息
Development. 2018 Jul 9;145(13):dev160887. doi: 10.1242/dev.160887.
Target of rapamycin (TOR) is an evolutionarily conserved protein kinase that plays a central role in both plants and animals, despite their distinct developmental programs and survival strategies. Indeed, TOR integrates nutrient, energy, hormone, growth factor and environmental inputs to control proliferation, growth and metabolism in diverse multicellular organisms. Here, we compare the molecular composition, upstream regulators and downstream signaling relays of TOR complexes in plants and animals. We also explore and discuss the pivotal functions of TOR signaling in basic cellular processes, such as translation, cell division and stem/progenitor cell regulation during plant development.
雷帕霉素靶蛋白（TOR）是一种进化上保守的蛋白激酶，在植物和动物中都发挥着核心作用，尽管它们具有截然不同的发育程序和生存策略。事实上，TOR 整合了营养物质、能量、激素、生长因子和环境输入，以控制不同多细胞生物的增殖、生长和代谢。在这里，我们比较了植物和动物中 TOR 复合物的分子组成、上游调节因子和下游信号转导途径。我们还探讨和讨论了 TOR 信号在基本细胞过程中的关键作用，例如在植物发育过程中的翻译、细胞分裂和干细胞/祖细胞调控。
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