植物中的 TOR 信号转导：保守与创新。
TOR signaling in plants: conservation and innovation.
机构信息
Department of Molecular Biology and Centre for Computational and Integrative Biology, Massachusetts General Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02114, USA.
Department of Molecular Biology and Centre for Computational and Integrative Biology, Massachusetts General Hospital, and Department of Genetics, Harvard Medical School, Boston, MA 02114, USA
出版信息
Development. 2018 Jul 9;145(13):dev160887. doi: 10.1242/dev.160887.
Abstract
Target of rapamycin (TOR) is an evolutionarily conserved protein kinase that plays a central role in both plants and animals, despite their distinct developmental programs and survival strategies. Indeed, TOR integrates nutrient, energy, hormone, growth factor and environmental inputs to control proliferation, growth and metabolism in diverse multicellular organisms. Here, we compare the molecular composition, upstream regulators and downstream signaling relays of TOR complexes in plants and animals. We also explore and discuss the pivotal functions of TOR signaling in basic cellular processes, such as translation, cell division and stem/progenitor cell regulation during plant development.
摘要
雷帕霉素靶蛋白（TOR）是一种进化上保守的蛋白激酶，在植物和动物中都发挥着核心作用，尽管它们具有截然不同的发育程序和生存策略。事实上，TOR 整合了营养物质、能量、激素、生长因子和环境输入，以控制不同多细胞生物的增殖、生长和代谢。在这里，我们比较了植物和动物中 TOR 复合物的分子组成、上游调节因子和下游信号转导途径。我们还探讨和讨论了 TOR 信号在基本细胞过程中的关键作用，例如在植物发育过程中的翻译、细胞分裂和干细胞/祖细胞调控。
相似文献
1
TOR signaling in plants: conservation and innovation.植物中的 TOR 信号转导：保守与创新。
Development. 2018 Jul 9;145(13):dev160887. doi: 10.1242/dev.160887.
2
The role of target of rapamycin signaling networks in plant growth and metabolism.雷帕霉素靶蛋白信号网络在植物生长和代谢中的作用。
Plant Physiol. 2014 Feb;164(2):499-512. doi: 10.1104/pp.113.229948. Epub 2014 Jan 2.
3
Novel links in the plant TOR kinase signaling network.植物雷帕霉素靶蛋白（TOR）激酶信号网络中的新联系。
Curr Opin Plant Biol. 2015 Dec;28:83-91. doi: 10.1016/j.pbi.2015.09.006. Epub 2015 Oct 24.
4
TOR in plants: Multidimensional regulators of plant growth and signaling pathways.植物中的 TOR：植物生长和信号通路的多维调节因子。
J Plant Physiol. 2024 Mar;294:154186. doi: 10.1016/j.jplph.2024.154186. Epub 2024 Feb 3.
5
Integration of nutrient, energy, light, and hormone signalling via TOR in plants.植物中通过 TOR 进行养分、能量、光照和激素信号的整合。
J Exp Bot. 2019 Apr 15;70(8):2227-2238. doi: 10.1093/jxb/erz028.
6
Sensing nutrient and energy status by SnRK1 and TOR kinases.通过 SnRK1 和 TOR 激酶感知营养和能量状态。
Curr Opin Plant Biol. 2012 Jun;15(3):301-7. doi: 10.1016/j.pbi.2012.01.012. Epub 2012 Feb 2.
7
The magic 'hammer' of TOR: the multiple faces of a single pathway in the metabolic regulation of plant growth and development.TOR 的神奇“锤子”：在植物生长发育的代谢调控中单一通路的多面性。
J Exp Bot. 2019 Apr 15;70(8):2217-2225. doi: 10.1093/jxb/ery459.
8
TOR Signaling and Nutrient Sensing.TOR 信号与营养感应。
Annu Rev Plant Biol. 2016 Apr 29;67:261-85. doi: 10.1146/annurev-arplant-043014-114648. Epub 2016 Feb 22.
9
TOR and SnRK1 signaling pathways in plant response to abiotic stresses: Do they always act according to the "yin-yang" model?TOR 和 SnRK1 信号通路在植物应对非生物胁迫中的作用：它们是否总是遵循“阴阳”模型？
Plant Sci. 2019 Nov;288:110220. doi: 10.1016/j.plantsci.2019.110220. Epub 2019 Aug 16.
10
A role for TOR signaling at every stage of plant life.TOR 信号在植物生命的各个阶段都发挥作用。
J Exp Bot. 2019 Apr 15;70(8):2285-2296. doi: 10.1093/jxb/erz125.
引用本文的文献
1
Maize big embryo 6 reveals roles of plastidial and cytosolic prephenate aminotransferases in seed and plant development.玉米大胚6揭示了质体和胞质预苯酸氨基转移酶在种子和植物发育中的作用。
Plant Cell. 2025 Jun 4;37(6). doi: 10.1093/plcell/koaf067.
2
is involved in root hair development in .参与了……中根毛的发育。 （原句不完整，信息缺失，此为根据现有内容的翻译）
Plant Signal Behav. 2025 Dec;20(1):2507736. doi: 10.1080/15592324.2025.2507736. Epub 2025 May 19.
3
Exploring FKBP12's Role in Enhancing Drought Tolerance in Rice.探索FKBP12在增强水稻耐旱性中的作用。
Rice (N Y). 2025 May 17;18(1):36. doi: 10.1186/s12284-025-00795-3.
4
Guard cell and whole plant expression of AtTOR improves performance under drought and enhances water use efficiency.拟南芥雷帕霉素靶蛋白（AtTOR）在保卫细胞和整株植物中的表达可提高干旱条件下的性能并增强水分利用效率。
J Biol Chem. 2025 May 13;301(6):110220. doi: 10.1016/j.jbc.2025.110220.
5
TOR Mediates Stress Responses Through Global Regulation of Metabolome in Plants.TOR通过对植物代谢组的全局调控介导应激反应。
Int J Mol Sci. 2025 Feb 27;26(5):2095. doi: 10.3390/ijms26052095.
6
A pangenome reveals LTR repeat dynamics as a major driver of genome evolution in Chenopodium.一个泛基因组揭示了长末端重复序列（LTR）的动态变化是藜属植物基因组进化的主要驱动力。
Plant Genome. 2025 Mar;18(1):e70010. doi: 10.1002/tpg2.70010.
7
Target of Rapamycin is a crucial regulator of photosynthesis and nutrient metabolism partitioning in Nannochloropsis gaditana.雷帕霉素靶蛋白是杜氏盐藻光合作用和营养物质代谢分配的关键调节因子。
Biotechnol Biofuels Bioprod. 2025 Feb 22;18(1):21. doi: 10.1186/s13068-025-02617-6.
8
Time-resolved oxidative signal convergence across the algae-embryophyte divide.跨越藻类与陆生植物界限的时间分辨氧化信号汇聚。
Nat Commun. 2025 Feb 19;16(1):1780. doi: 10.1038/s41467-025-56939-y.
9
NgLst8 Coactivates TOR Signaling to Activate Photosynthetic Growth in .NgLst8 共激活 TOR 信号传导以激活光合作用生长 。 （原文句子不完整，此为按现有内容翻译）
Microorganisms. 2024 Dec 13;12(12):2574. doi: 10.3390/microorganisms12122574.
10
BATF alleviates ox-LDL-induced HCAEC injury by regulating SIRT1 expression in coronary heart disease.BATF通过调节冠心病中SIRT1的表达减轻氧化型低密度脂蛋白诱导的人冠状动脉内皮细胞损伤。
PLoS One. 2024 Dec 16;19(12):e0306514. doi: 10.1371/journal.pone.0306514. eCollection 2024.
本文引用的文献
1
Autophagy: The Master of Bulk and Selective Recycling.自噬：批量和选择性回收的大师。
Annu Rev Plant Biol. 2018 Apr 29;69:173-208. doi: 10.1146/annurev-arplant-042817-040606. Epub 2018 Mar 14.
2
The SnRK1 Kinase as Central Mediator of Energy Signaling between Different Organelles.SnRK1 激酶作为不同细胞器之间能量信号的中心介质。
Plant Physiol. 2018 Feb;176(2):1085-1094. doi: 10.1104/pp.17.01404. Epub 2018 Jan 8.
3
mTOR signaling in stem and progenitor cells.干细胞和祖细胞中的mTOR信号传导。
Development. 2018 Jan 8;145(1):dev152595. doi: 10.1242/dev.152595.
4
Reciprocal Regulation of the TOR Kinase and ABA Receptor Balances Plant Growth and Stress Response.TOR 激酶和 ABA 受体的相互调节平衡植物生长和应激反应。
Mol Cell. 2018 Jan 4;69(1):100-112.e6. doi: 10.1016/j.molcel.2017.12.002. Epub 2017 Dec 28.
5
Recent Discoveries on the Role of TOR (Target of Rapamycin) Signaling in Translation in Plants.近年来关于 TOR（雷帕霉素靶蛋白）信号在植物翻译中的作用的新发现。
Plant Physiol. 2018 Feb;176(2):1095-1105. doi: 10.1104/pp.17.01243. Epub 2017 Nov 9.
6
Evolutionary Conservation of the Components in the TOR Signaling Pathways.TOR 信号通路组件的进化保守性。
Biomolecules. 2017 Nov 1;7(4):77. doi: 10.3390/biom7040077.
7
Family Genes Are Involved in Translation Control, Especially under Energy-Deficient Conditions, and Their Expression and Functions Are Modulated by the TOR Signaling Pathway.家族基因参与翻译控制，特别是在能量不足的情况下，它们的表达和功能受 TOR 信号通路的调节。
Plant Cell. 2017 Nov;29(11):2895-2920. doi: 10.1105/tpc.17.00563. Epub 2017 Oct 30.
8
Sulfur availability regulates plant growth via glucose-TOR signaling.硫供应通过葡萄糖-TOR 信号调控植物生长。
Nat Commun. 2017 Oct 27;8(1):1174. doi: 10.1038/s41467-017-01224-w.
9
The mTOR-Bach2 Cascade Controls Cell Cycle and Class Switch Recombination during B Cell Differentiation.mTOR-Bach2 级联在 B 细胞分化过程中控制细胞周期和类别转换重排。
Mol Cell Biol. 2017 Nov 28;37(24). doi: 10.1128/MCB.00418-17. Print 2017 Dec 15.
10
AMPK: guardian of metabolism and mitochondrial homeostasis.AMPK：代谢和线粒体动态平衡的守护者。
Nat Rev Mol Cell Biol. 2018 Feb;19(2):121-135. doi: 10.1038/nrm.2017.95. Epub 2017 Oct 4.
Zotero 插件