Program of Glycobiology, Institute of Medical Biochemistry Leopoldo de Meis, and University Hospital Clementino Fraga Filho, Federal University of Rio de Janeiro, Rio de Janeiro, RJ 21941-913, Brazil.
Department of BioMolecular Sciences, Division of Pharmacognosy, and Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, Oxford, MS 38677-1848, USA.
Mar Drugs. 2018 Jul 9;16(7):233. doi: 10.3390/md16070233.
The oceans harbor a great diversity of organisms, and have been recognized as an important source of new compounds with nutritional and therapeutic potential. Among these compounds, carbohydrate-based compounds are of particular interest because they exhibit numerous biological functions associated with their chemical diversity. This gives rise to new substances for the development of bioactive products. Many are the known applications of substances with glycosidic domains obtained from marine species. This review covers the structural properties and the current findings on the antioxidant, anti-inflammatory, anticoagulant, antitumor and antimicrobial activities of medium and high molecular-weight carbohydrates or glycosylated compounds extracted from various marine organisms.
海洋中蕴藏着丰富多样的生物，这些生物已被证实是具有营养和治疗潜力的新型化合物的重要来源。在这些化合物中，基于碳水化合物的化合物尤其受到关注，因为它们表现出许多与化学多样性相关的生物功能。这为生物活性产品的开发提供了新的物质。从海洋物种中获得的具有糖苷结构域的物质已经有许多已知的应用。本文综述了从中等和高分子量碳水化合物或从各种海洋生物中提取的糖基化化合物的结构特性，以及它们在抗氧化、抗炎、抗凝血、抗肿瘤和抗菌活性方面的最新研究进展。
